The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus

Heterochromatin is a structurally compacted region of chromosomes in which transcription and recombination are inactivated. DNA replication is temporally regulated in heterochromatin, but the molecular mechanism for regulation has not been elucidated. Among heterochromatin loci in Schizosaccharomyce...

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Veröffentlicht in:	Nature cell biology 2009-03, Vol.11 (3), p.357-362
Hauptverfasser:	Takahashi, Tatsuro S, Nakayama, Jun-ichi, Masukata, Hisao, Hayashi, Makoto T, Nakagawa, Takuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Biomedical and Life Sciences Cancer Research Cell Biology Cell cycle Cellular proteins Centromere - metabolism Chromosomal Proteins, Non-Histone - metabolism Chromosomes Deoxyribonucleic acid Developmental Biology DNA DNA methylation DNA replication DNA Replication Timing Efficiency Genes, Mating Type, Fungal Heterochromatin - metabolism Kinases letter Life Sciences Models, Biological Physiological aspects Point Mutation - genetics Protein Binding Protein Transport Proteins Replication Origin S Phase Schizosaccharomyces - genetics Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - chemistry Schizosaccharomyces pombe Proteins - metabolism Stem Cells Yeast
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