Activation of programmed cell death markers in ventral horn motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in a transgenic mouse model

The identification of the pathogenic mechanism of selective motor neuron (MN) death in amyotrophic lateral sclerosis (ALS) may lead to the development of new therapies to halt or slow the disease course. A novel, MN-specific, Fas-mediated programmed cell death (PCD) pathway has been reported in MNs...

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Veröffentlicht in:	Brain research 2004-11, Vol.1027 (1), p.73-86
Hauptverfasser:	Wengenack, Thomas M., Holasek, Silvina S., Montano, Carolina M., Gregor, Dawn, Curran, Geoffry L., Poduslo, Joseph F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active caspase-3 Age Factors Amyotrophic Lateral Sclerosis - diagnosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animals Anterior Horn Cells - cytology Anterior Horn Cells - metabolism Apoptosis Apoptosis - physiology ASK1 Biological and medical sciences Biomarkers - metabolism Blotting, Western - methods Caspase 3 Caspases - metabolism Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal fas Receptor - metabolism Humans Immunohistochemistry - methods MAP Kinase Kinase Kinase 5 - metabolism Medical sciences Mice Mice, Transgenic - physiology Neurology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I nNOS p38 p38 Mitogen-Activated Protein Kinases - metabolism SAPK/JNK Staining and Labeling - methods Superoxide Dismutase - genetics
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