High-resolution functional vascular assessment with ultrasound
In order to improve the resolution of contrast-assisted imaging systems, we have created a high-frequency destruction/contrast replenishment imaging system with a spatial resolution of 160 /spl mu/m /spl times/ 160 /spl mu/m. The system utilizes a 1-MHz cylindrically focused transducer for destructi...
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| Veröffentlicht in: | IEEE transactions on medical imaging 2004-10, Vol.23 (10), p.1263-1275 |
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| creator | Chih-Kuang Yeh Ferrara, K.W. Kruse, D.E. |
| description | In order to improve the resolution of contrast-assisted imaging systems, we have created a high-frequency destruction/contrast replenishment imaging system with a spatial resolution of 160 /spl mu/m /spl times/ 160 /spl mu/m. The system utilizes a 1-MHz cylindrically focused transducer for destruction and a 25-MHz spherically focused transducer for pulse/echo imaging. Speckle tracking and a clutter filter are applied across frames to remove the challenging physiologic motion artifacts that are obtained when imaging with a mechanically scanned transducer. Using a new estimation technique, flow constants proportional to absolute flow rate were estimated from B-mode time-intensity curves (TICs). The in vitro results indicate a correlation between the actual flow velocity and the estimated rate constant. In vivo images are presented showing blood perfusion in the ciliary processes and iris of the rabbit eye. The regions of interest (ROIs) from the ciliary processes yielded slower perfusion compared with the iris, as expected from vascular casts of the microcirculation in this region. Potential applications of this system include high-resolution perfusion assessment in small animals. |
| doi_str_mv | 10.1109/TMI.2004.834614 |
| format | Article |
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The system utilizes a 1-MHz cylindrically focused transducer for destruction and a 25-MHz spherically focused transducer for pulse/echo imaging. Speckle tracking and a clutter filter are applied across frames to remove the challenging physiologic motion artifacts that are obtained when imaging with a mechanically scanned transducer. Using a new estimation technique, flow constants proportional to absolute flow rate were estimated from B-mode time-intensity curves (TICs). The in vitro results indicate a correlation between the actual flow velocity and the estimated rate constant. In vivo images are presented showing blood perfusion in the ciliary processes and iris of the rabbit eye. The regions of interest (ROIs) from the ciliary processes yielded slower perfusion compared with the iris, as expected from vascular casts of the microcirculation in this region. Potential applications of this system include high-resolution perfusion assessment in small animals.</description><identifier>ISSN: 0278-0062</identifier><identifier>EISSN: 1558-254X</identifier><identifier>DOI: 10.1109/TMI.2004.834614</identifier><identifier>PMID: 15493694</identifier><identifier>CODEN: ITMID4</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Algorithms ; Animals ; Blood Flow Velocity - physiology ; Ciliary Body - blood supply ; Ciliary Body - diagnostic imaging ; Ciliary Body - physiology ; Computer Simulation ; Equipment Design ; Equipment Failure Analysis ; Filters ; Flow velocity ; Focusing ; High-resolution imaging ; Image Enhancement - instrumentation ; Image Enhancement - methods ; Image Interpretation, Computer-Assisted - methods ; Image resolution ; Information Storage and Retrieval - methods ; Iris ; Iris - blood supply ; Iris - diagnostic imaging ; Iris - physiology ; Microbubbles ; Microcirculation - diagnostic imaging ; Microcirculation - physiology ; Models, Cardiovascular ; Phantoms, Imaging ; Rabbits ; Reproducibility of Results ; Sensitivity and Specificity ; Signal Processing, Computer-Assisted ; Spatial resolution ; Speckle ; Tracking ; Ultrasonic imaging ; Ultrasonic transducers ; Ultrasonography, Doppler - instrumentation ; Ultrasonography, Doppler - methods</subject><ispartof>IEEE transactions on medical imaging, 2004-10, Vol.23 (10), p.1263-1275</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2004</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-85596e2e5fff3d678cfb36dfd8bde0eed7a096060a41e63650b0d01a9410a9863</citedby><cites>FETCH-LOGICAL-c434t-85596e2e5fff3d678cfb36dfd8bde0eed7a096060a41e63650b0d01a9410a9863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/1339433$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,780,784,796,27924,27925,54758</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/1339433$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15493694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chih-Kuang Yeh</creatorcontrib><creatorcontrib>Ferrara, K.W.</creatorcontrib><creatorcontrib>Kruse, D.E.</creatorcontrib><title>High-resolution functional vascular assessment with ultrasound</title><title>IEEE transactions on medical imaging</title><addtitle>TMI</addtitle><addtitle>IEEE Trans Med Imaging</addtitle><description>In order to improve the resolution of contrast-assisted imaging systems, we have created a high-frequency destruction/contrast replenishment imaging system with a spatial resolution of 160 /spl mu/m /spl times/ 160 /spl mu/m. The system utilizes a 1-MHz cylindrically focused transducer for destruction and a 25-MHz spherically focused transducer for pulse/echo imaging. Speckle tracking and a clutter filter are applied across frames to remove the challenging physiologic motion artifacts that are obtained when imaging with a mechanically scanned transducer. Using a new estimation technique, flow constants proportional to absolute flow rate were estimated from B-mode time-intensity curves (TICs). The in vitro results indicate a correlation between the actual flow velocity and the estimated rate constant. In vivo images are presented showing blood perfusion in the ciliary processes and iris of the rabbit eye. The regions of interest (ROIs) from the ciliary processes yielded slower perfusion compared with the iris, as expected from vascular casts of the microcirculation in this region. Potential applications of this system include high-resolution perfusion assessment in small animals.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Blood Flow Velocity - physiology</subject><subject>Ciliary Body - blood supply</subject><subject>Ciliary Body - diagnostic imaging</subject><subject>Ciliary Body - physiology</subject><subject>Computer Simulation</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Filters</subject><subject>Flow velocity</subject><subject>Focusing</subject><subject>High-resolution imaging</subject><subject>Image Enhancement - instrumentation</subject><subject>Image Enhancement - methods</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Image resolution</subject><subject>Information Storage and Retrieval - methods</subject><subject>Iris</subject><subject>Iris - blood supply</subject><subject>Iris - diagnostic imaging</subject><subject>Iris - physiology</subject><subject>Microbubbles</subject><subject>Microcirculation - diagnostic imaging</subject><subject>Microcirculation - physiology</subject><subject>Models, Cardiovascular</subject><subject>Phantoms, Imaging</subject><subject>Rabbits</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Spatial resolution</subject><subject>Speckle</subject><subject>Tracking</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic transducers</subject><subject>Ultrasonography, Doppler - instrumentation</subject><subject>Ultrasonography, Doppler - methods</subject><issn>0278-0062</issn><issn>1558-254X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNqFkc1LwzAYh4Mobk7PHgQpHvTU7U3z0eQiyPBjMPEywVvJ2reuo2tn0ij-97ZuMPDgDi954ffkR8hDyDmFIaWgR7PnyTAC4EPFuKT8gPSpECqMBH87JH2IYhUCyKhHTpxbAlAuQB-THhVcM6l5n9w-Fe-L0KKrS98UdRXkvkq7xZTBp3GpL40NjHPo3AqrJvgqmkXgy8YaV_sqOyVHuSkdnm3PAXl9uJ-Nn8Lpy-NkfDcNU854EyohtMQIRZ7nLJOxSvM5k1meqXmGgJjFBrQECYZTlEwKmEMG1GhOwWgl2YDcbHrXtv7w6JpkVbgUy9JUWHuXKMWAx-205PW_pJRaCRnDXjBSLIqp2t9I40hLrVkLXv0Bl7W37U_-vk8D06xrG22g1NbOWcyTtS1Wxn4nFJLOadI6TTqnycZpe-NyW-vnK8x2_FZiC1xsgAIRdzFjbcbYD7k9pFQ</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Chih-Kuang Yeh</creator><creator>Ferrara, K.W.</creator><creator>Kruse, D.E.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>RIA</scope><scope>RIE</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>High-resolution functional vascular assessment with ultrasound</title><author>Chih-Kuang Yeh ; Ferrara, K.W. ; Kruse, D.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-85596e2e5fff3d678cfb36dfd8bde0eed7a096060a41e63650b0d01a9410a9863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Blood Flow Velocity - physiology</topic><topic>Ciliary Body - blood supply</topic><topic>Ciliary Body - diagnostic imaging</topic><topic>Ciliary Body - physiology</topic><topic>Computer Simulation</topic><topic>Equipment Design</topic><topic>Equipment Failure Analysis</topic><topic>Filters</topic><topic>Flow velocity</topic><topic>Focusing</topic><topic>High-resolution imaging</topic><topic>Image Enhancement - instrumentation</topic><topic>Image Enhancement - methods</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Image resolution</topic><topic>Information Storage and Retrieval - methods</topic><topic>Iris</topic><topic>Iris - blood supply</topic><topic>Iris - diagnostic imaging</topic><topic>Iris - physiology</topic><topic>Microbubbles</topic><topic>Microcirculation - diagnostic imaging</topic><topic>Microcirculation - physiology</topic><topic>Models, Cardiovascular</topic><topic>Phantoms, Imaging</topic><topic>Rabbits</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Spatial resolution</topic><topic>Speckle</topic><topic>Tracking</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonic transducers</topic><topic>Ultrasonography, Doppler - instrumentation</topic><topic>Ultrasonography, Doppler - methods</topic><toplevel>online_resources</toplevel><creatorcontrib>Chih-Kuang Yeh</creatorcontrib><creatorcontrib>Ferrara, K.W.</creatorcontrib><creatorcontrib>Kruse, D.E.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>IEEE transactions on medical imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chih-Kuang Yeh</au><au>Ferrara, K.W.</au><au>Kruse, D.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-resolution functional vascular assessment with ultrasound</atitle><jtitle>IEEE transactions on medical imaging</jtitle><stitle>TMI</stitle><addtitle>IEEE Trans Med Imaging</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>23</volume><issue>10</issue><spage>1263</spage><epage>1275</epage><pages>1263-1275</pages><issn>0278-0062</issn><eissn>1558-254X</eissn><coden>ITMID4</coden><abstract>In order to improve the resolution of contrast-assisted imaging systems, we have created a high-frequency destruction/contrast replenishment imaging system with a spatial resolution of 160 /spl mu/m /spl times/ 160 /spl mu/m. The system utilizes a 1-MHz cylindrically focused transducer for destruction and a 25-MHz spherically focused transducer for pulse/echo imaging. Speckle tracking and a clutter filter are applied across frames to remove the challenging physiologic motion artifacts that are obtained when imaging with a mechanically scanned transducer. Using a new estimation technique, flow constants proportional to absolute flow rate were estimated from B-mode time-intensity curves (TICs). The in vitro results indicate a correlation between the actual flow velocity and the estimated rate constant. In vivo images are presented showing blood perfusion in the ciliary processes and iris of the rabbit eye. The regions of interest (ROIs) from the ciliary processes yielded slower perfusion compared with the iris, as expected from vascular casts of the microcirculation in this region. Potential applications of this system include high-resolution perfusion assessment in small animals.</abstract><cop>United States</cop><pub>IEEE</pub><pmid>15493694</pmid><doi>10.1109/TMI.2004.834614</doi><tpages>13</tpages></addata></record> |
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| subjects | Algorithms Animals Blood Flow Velocity - physiology Ciliary Body - blood supply Ciliary Body - diagnostic imaging Ciliary Body - physiology Computer Simulation Equipment Design Equipment Failure Analysis Filters Flow velocity Focusing High-resolution imaging Image Enhancement - instrumentation Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Image resolution Information Storage and Retrieval - methods Iris Iris - blood supply Iris - diagnostic imaging Iris - physiology Microbubbles Microcirculation - diagnostic imaging Microcirculation - physiology Models, Cardiovascular Phantoms, Imaging Rabbits Reproducibility of Results Sensitivity and Specificity Signal Processing, Computer-Assisted Spatial resolution Speckle Tracking Ultrasonic imaging Ultrasonic transducers Ultrasonography, Doppler - instrumentation Ultrasonography, Doppler - methods |
| title | High-resolution functional vascular assessment with ultrasound |
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