Reevaluation of solubility of tolbutamide and polymorphic transformation from Form I to unknown crystal form

Thermodynamic stability order of tolbutamide between polymorphs was evaluated using calorimetry and spectroscopic analysis. The heat of solution (Δ H) of Forms I–III measurements were carried out in dimethylsulfoxide between 298.2 K and 319.2 K. It was found that the Δ H of Forms II and III was incr...

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