Role of human Ku86 in telomere length maintenance and telomere capping

The role of Ku86 at telomeres has been extensively studied in various organisms; however, a role for Ku86 at human telomeres was unknown because Ku86 deletion is lethal for human cells. Here, we used small interference RNA to decrease Ku86 protein levels in human cells. An approximately 50% reductio...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-10, Vol.64 (20), p.7271-7278
Hauptverfasser:	JACO, Isabel, MUNOZ, Purificacion, BLASCO, Maria A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear - genetics Antigens, Nuclear - physiology Antineoplastic agents Apoptosis - genetics Biological and medical sciences Cell Division - genetics Cell Line, Tumor Chromatids - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology HeLa Cells Humans Ku Autoantigen Medical sciences Mice Pharmacology. Drug treatments RNA, Small Interfering - genetics Telomerase - metabolism Telomere - genetics Telomere - physiology Tumors
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