Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit

The ethanol extract from the fruit of Terminalia chebula (Combretaceae) exhibited signiﬁcant inhibitory activity on oxidative stress and the age‐dependent shortening of the telomeric DNA length. In the peroxidation model using t‐BuOOH, the T. chebula extract showed a notable cytoprotective effect on...

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Veröffentlicht in:	Phytotherapy research 2004-09, Vol.18 (9), p.737-741
Hauptverfasser:	Na, M.K, Bae, K.H, Kang, S.S, Min, B.S, Yoo, J.K, Kamiryo, Y, Senoo, Y.I, Yokoo, S, Miwa, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Combretaceae DNA - drug effects Fruit General pharmacology Humans Medical sciences oxidative stress Oxidative Stress - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Protective Agents - administration & dosage Protective Agents - pharmacology Protective Agents - therapeutic use Skin Aging - drug effects Skin Aging - radiation effects Southern blots Telomere - drug effects telomere length Terminalia Terminalia chebula Ultraviolet Rays
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creator	Na, M.K Bae, K.H Kang, S.S Min, B.S Yoo, J.K Kamiryo, Y Senoo, Y.I Yokoo, S Miwa, N
description	The ethanol extract from the fruit of Terminalia chebula (Combretaceae) exhibited signiﬁcant inhibitory activity on oxidative stress and the age‐dependent shortening of the telomeric DNA length. In the peroxidation model using t‐BuOOH, the T. chebula extract showed a notable cytoprotective effect on the HEK‐N/F cells with 60.5 ± 3.8% at a concentration of 50 µg/ml. In addition, the T. chebula extract exhibited a signiﬁcant cytoprotective effect against UVB‐induced oxidative damage. The life‐span of the HEK‐N/F cells was elongated by 40% as a result of the continuous administration of 3 µg/ml of the T. chebula extract compared to that of the control. These observations were attributed to the inhibitory effect of the T. chebula extract on the age‐dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages. Copyright © 2004 John Wiley & Sons, Ltd.
doi_str_mv	10.1002/ptr.1529
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In the peroxidation model using t‐BuOOH, the T. chebula extract showed a notable cytoprotective effect on the HEK‐N/F cells with 60.5 ± 3.8% at a concentration of 50 µg/ml. In addition, the T. chebula extract exhibited a signiﬁcant cytoprotective effect against UVB‐induced oxidative damage. The life‐span of the HEK‐N/F cells was elongated by 40% as a result of the continuous administration of 3 µg/ml of the T. chebula extract compared to that of the control. These observations were attributed to the inhibitory effect of the T. chebula extract on the age‐dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages. 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Drug treatments ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Protective Agents - administration & dosage ; Protective Agents - pharmacology ; Protective Agents - therapeutic use ; Skin Aging - drug effects ; Skin Aging - radiation effects ; Southern blots ; Telomere - drug effects ; telomere length ; Terminalia ; Terminalia chebula ; Ultraviolet Rays</subject><ispartof>Phytotherapy research, 2004-09, Vol.18 (9), p.737-741</ispartof><rights>Copyright © 2004 John Wiley & Sons, Ltd.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright (c) 2004 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4759-849ef83e03b57450f8f82b281f724cc580a8a5d8e70f1f905012b93a59fe08393</citedby><cites>FETCH-LOGICAL-c4759-849ef83e03b57450f8f82b281f724cc580a8a5d8e70f1f905012b93a59fe08393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.1529$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.1529$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16196232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15478203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Na, M.K</creatorcontrib><creatorcontrib>Bae, K.H</creatorcontrib><creatorcontrib>Kang, S.S</creatorcontrib><creatorcontrib>Min, B.S</creatorcontrib><creatorcontrib>Yoo, J.K</creatorcontrib><creatorcontrib>Kamiryo, Y</creatorcontrib><creatorcontrib>Senoo, Y.I</creatorcontrib><creatorcontrib>Yokoo, S</creatorcontrib><creatorcontrib>Miwa, N</creatorcontrib><title>Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The ethanol extract from the fruit of Terminalia chebula (Combretaceae) exhibited signiﬁcant inhibitory activity on oxidative stress and the age‐dependent shortening of the telomeric DNA length. In the peroxidation model using t‐BuOOH, the T. chebula extract showed a notable cytoprotective effect on the HEK‐N/F cells with 60.5 ± 3.8% at a concentration of 50 µg/ml. In addition, the T. chebula extract exhibited a signiﬁcant cytoprotective effect against UVB‐induced oxidative damage. The life‐span of the HEK‐N/F cells was elongated by 40% as a result of the continuous administration of 3 µg/ml of the T. chebula extract compared to that of the control. These observations were attributed to the inhibitory effect of the T. chebula extract on the age‐dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages. Copyright © 2004 John Wiley & Sons, Ltd.</description><subject>Biological and medical sciences</subject><subject>Combretaceae</subject><subject>DNA - drug effects</subject><subject>Fruit</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Protective Agents - administration & dosage</subject><subject>Protective Agents - pharmacology</subject><subject>Protective Agents - therapeutic use</subject><subject>Skin Aging - drug effects</subject><subject>Skin Aging - radiation effects</subject><subject>Southern blots</subject><subject>Telomere - drug effects</subject><subject>telomere length</subject><subject>Terminalia</subject><subject>Terminalia chebula</subject><subject>Ultraviolet Rays</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c9vFCEUB3BibOy2mvgXKBcbL1MfMMzA0Wzabpv6I3UbvRFmFrbozLAFRrv_vaw7sV48QeCT9x5fEHpJ4JQA0HebFE4Jp_IJmhGQsiC8Zk_RDCQnRUnEt0N0FON3AJAUymfokPCyFhTYDPXzbfKb4JNpk_tpsLE277AfsH9wK_3nLKZgYsR6WGE33LnGJR-2_8jWdN3Y6YD12g1r7C1emtC7QXdO4_bONPkS2zC69BwdWN1F82Jaj9Ht-dlyviiuP11czt9fF21Zc1mIUhormAHW8LrkYIUVtKGC2JqWbcsFaKH5SpgaLLESOBDaSKa5tAYEk-wYnezr5pfdjyYm1bu4G1MPxo9RVZUULEeQ4ds9bIOPMRirNsH1OmwVAbWLVuVo1S7aTF9NNcemN6tHOGWZwZsJ6NjqzgY9tC4-uorIijKaXbF3v1xntv9tqD4vb6bGk3cxmYe_XocfqqpZzdXXjxdqsTiX5dXNlfqQ_eu9t9orvQ55htsvFAjL3y-AiIr9BqKCqNo</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Na, M.K</creator><creator>Bae, K.H</creator><creator>Kang, S.S</creator><creator>Min, B.S</creator><creator>Yoo, J.K</creator><creator>Kamiryo, Y</creator><creator>Senoo, Y.I</creator><creator>Yokoo, S</creator><creator>Miwa, N</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit</title><author>Na, M.K ; Bae, K.H ; Kang, S.S ; Min, B.S ; Yoo, J.K ; Kamiryo, Y ; Senoo, Y.I ; Yokoo, S ; Miwa, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4759-849ef83e03b57450f8f82b281f724cc580a8a5d8e70f1f905012b93a59fe08393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Combretaceae</topic><topic>DNA - drug effects</topic><topic>Fruit</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacognosy. 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These observations were attributed to the inhibitory effect of the T. chebula extract on the age‐dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages. Copyright © 2004 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>15478203</pmid><doi>10.1002/ptr.1529</doi><tpages>5</tpages></addata></record>
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subjects	Biological and medical sciences Combretaceae DNA - drug effects Fruit General pharmacology Humans Medical sciences oxidative stress Oxidative Stress - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Protective Agents - administration & dosage Protective Agents - pharmacology Protective Agents - therapeutic use Skin Aging - drug effects Skin Aging - radiation effects Southern blots Telomere - drug effects telomere length Terminalia Terminalia chebula Ultraviolet Rays
title	Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit
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