Growth promoting signaling by tenascin-C [corrected]

Tenascin-C is an adhesion-modulating extracellular matrix molecule that is highly expressed in tumor stroma and stimulates tumor cell proliferation. Adhesion of T98G glioblastoma cells to a fibronectin substratum is inhibited by tenascin-C. To address the mechanism of action, we performed a RNA expr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-10, Vol.64 (20), p.7377-7385
Hauptverfasser:	Ruiz, Christian, Huang, Wentao, Hegi, Monika E, Lange, Katrin, Hamou, Marie-France, Fluri, Erika, Oakeley, Edward J, Chiquet-Ehrismann, Ruth, Orend, Gertraud
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Cell Growth Processes - drug effects Cell Line, Tumor Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Down-Regulation - drug effects Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Humans Inhibitor of Differentiation Protein 2 MAP Kinase Signaling System - drug effects Proto-Oncogene Proteins - physiology Repressor Proteins - biosynthesis Repressor Proteins - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Signal Transduction - drug effects Tenascin - pharmacology Transcription Factors - biosynthesis Transcription Factors - genetics Tropomyosin - biosynthesis Wnt Proteins
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