Encapsulation, stabilization, and release of BSA-FITC from polyanhydride microspheres

In order to determine the efficacy of using polyanhydrides as a carrier for therapeutic proteins, the model protein bovine serum albumin labeled with fluorescein isothiocyanate (BSA-FITC) was encapsulated in microspheres of poly sebacic anhydride (poly(SA)), and random copolymers of poly(SA) and pol...

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Veröffentlicht in:	Journal of controlled release 2004-11, Vol.100 (1), p.97-109
Hauptverfasser:	Determan, Amy S., Trewyn, Brian G., Lin, Victor S.-Y., Nilsen-Hamilton, Marit, Narasimhan, Balaji
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bovine serum albumin Electrophoresis, Polyacrylamide Gel Fluorescein-5-isothiocyanate - administration & dosage Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - chemistry General pharmacology Medical sciences Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyanhydrides Polyanhydrides - administration & dosage Primary structure Secondary structure Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - chemistry Spectroscopy, Fourier Transform Infrared Stabilized
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