Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids
The crude extract of Mahonia aquifolium (Pursh) Nutt. stem bark and its two main protoberberine alkaloids, berberine and jatrorrhizine, were tested for their in vitro antimicrobial activity. Twenty strains of coagulase‐negative staphylococci and 20 strains of Propionibacterium acnes isolated from sk...
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| Veröffentlicht in: | Phytotherapy research 2004-08, Vol.18 (8), p.674-676 |
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| container_title | Phytotherapy research |
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| creator | Slobodníková, Lívia KoSt'álová, Daniela Labudová, Darina Kotulová, Daniela Kettmann, Viktor |
| description | The crude extract of Mahonia aquifolium (Pursh) Nutt. stem bark and its two main protoberberine alkaloids, berberine and jatrorrhizine, were tested for their in vitro antimicrobial activity. Twenty strains of coagulase‐negative staphylococci and 20 strains of Propionibacterium acnes isolated from skin lesions of patients with a severe form of acne, and 20 strains of Candida sp. isolated from chronic vulvovaginal candidoses were tested for their susceptibility to crude extract and two isolated alkaloids. The minimum inhibitory concentrations obtained in this study illustrate the varying degrees of antibacterial and antifungal activity of the tested agents. The results indicate a rational basis for the traditional use of Mahonia aquifolium for localized skin and mucosal infection therapy, as well as for the possible development of a preparation for supportive therapy of the diseases mentioned above. Copyright © 2004 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.1517 |
| format | Article |
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Twenty strains of coagulase‐negative staphylococci and 20 strains of Propionibacterium acnes isolated from skin lesions of patients with a severe form of acne, and 20 strains of Candida sp. isolated from chronic vulvovaginal candidoses were tested for their susceptibility to crude extract and two isolated alkaloids. The minimum inhibitory concentrations obtained in this study illustrate the varying degrees of antibacterial and antifungal activity of the tested agents. The results indicate a rational basis for the traditional use of Mahonia aquifolium for localized skin and mucosal infection therapy, as well as for the possible development of a preparation for supportive therapy of the diseases mentioned above. Copyright © 2004 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.1517</identifier><identifier>PMID: 15476315</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - pharmacology ; Anti-Infective Agents - therapeutic use ; antimicrobial activity ; Berberine - administration & dosage ; Berberine - analogs & derivatives ; Berberine - pharmacology ; Berberine - therapeutic use ; Berberine Alkaloids - administration & dosage ; Berberine Alkaloids - pharmacology ; Berberine Alkaloids - therapeutic use ; Biological and medical sciences ; Candida - classification ; Candida - drug effects ; General pharmacology ; Humans ; Mahonia ; Mahonia aquifolium ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Stems ; Propionibacterium acnes - classification ; Propionibacterium acnes - drug effects ; protoberberine alkaloids ; Staphylococcus - classification ; Staphylococcus - drug effects</subject><ispartof>Phytotherapy research, 2004-08, Vol.18 (8), p.674-676</ispartof><rights>Copyright © 2004 John Wiley & Sons, Ltd.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3857-e04fb7adcb169d545c81136d19b2b94252b77607f35220f9e8fd75125bdb08023</citedby><cites>FETCH-LOGICAL-c3857-e04fb7adcb169d545c81136d19b2b94252b77607f35220f9e8fd75125bdb08023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.1517$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.1517$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16140171$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15476315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slobodníková, Lívia</creatorcontrib><creatorcontrib>KoSt'álová, Daniela</creatorcontrib><creatorcontrib>Labudová, Darina</creatorcontrib><creatorcontrib>Kotulová, Daniela</creatorcontrib><creatorcontrib>Kettmann, Viktor</creatorcontrib><title>Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The crude extract of Mahonia aquifolium (Pursh) Nutt. stem bark and its two main protoberberine alkaloids, berberine and jatrorrhizine, were tested for their in vitro antimicrobial activity. Twenty strains of coagulase‐negative staphylococci and 20 strains of Propionibacterium acnes isolated from skin lesions of patients with a severe form of acne, and 20 strains of Candida sp. isolated from chronic vulvovaginal candidoses were tested for their susceptibility to crude extract and two isolated alkaloids. The minimum inhibitory concentrations obtained in this study illustrate the varying degrees of antibacterial and antifungal activity of the tested agents. The results indicate a rational basis for the traditional use of Mahonia aquifolium for localized skin and mucosal infection therapy, as well as for the possible development of a preparation for supportive therapy of the diseases mentioned above. Copyright © 2004 John Wiley & Sons, Ltd.</description><subject>Anti-Infective Agents - administration & dosage</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>antimicrobial activity</subject><subject>Berberine - administration & dosage</subject><subject>Berberine - analogs & derivatives</subject><subject>Berberine - pharmacology</subject><subject>Berberine - therapeutic use</subject><subject>Berberine Alkaloids - administration & dosage</subject><subject>Berberine Alkaloids - pharmacology</subject><subject>Berberine Alkaloids - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Candida - classification</subject><subject>Candida - drug effects</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Mahonia</subject><subject>Mahonia aquifolium</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Stems</subject><subject>Propionibacterium acnes - classification</subject><subject>Propionibacterium acnes - drug effects</subject><subject>protoberberine alkaloids</subject><subject>Staphylococcus - classification</subject><subject>Staphylococcus - drug effects</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EFPFTEUBeDGaOSBJv4C043GzUBvO51Ol0AUTRCBQCRx0XTaTix0po-2g7x_75A3kZWru_lyTu5B6B2QfSCEHqxL2gcO4gVaAZGyAi7YS7QikkNVQ3uzg3ZzviWESErq12gHeC0aBnyFfh2OxQ_epNh5HbA2xT_4ssGxx9_17zh6jfX95PsY_DRgkybrsHssaYZYjxb7kvGgb2PCPsegi7NYhzsdorf5DXrV65Dd2-Xuoesvn6-Ov1anP06-HR-eVoa1XFSO1H0ntDUdNNLympsWgDUWZEc7WVNOOyEaInrGKSW9dG1vBQfKO9uRllC2hz5uc9cp3k8uFzX4bFwIenRxyqppZEsFrWf4aQvnd3NOrlfr5AedNgqIehpSzUOqpyFn-n7JnLrB2We4LDeDDwvQ2ejQJz0an59dAzUBAbOrtu6PD27z30J1fnW5FC_e5-Ie_3md7lQjmODq59mJEs3F0TmjF-qG_QWjMZjZ</recordid><startdate>200408</startdate><enddate>200408</enddate><creator>Slobodníková, Lívia</creator><creator>KoSt'álová, Daniela</creator><creator>Labudová, Darina</creator><creator>Kotulová, Daniela</creator><creator>Kettmann, Viktor</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200408</creationdate><title>Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids</title><author>Slobodníková, Lívia ; KoSt'álová, Daniela ; Labudová, Darina ; Kotulová, Daniela ; Kettmann, Viktor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3857-e04fb7adcb169d545c81136d19b2b94252b77607f35220f9e8fd75125bdb08023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anti-Infective Agents - administration & dosage</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>antimicrobial activity</topic><topic>Berberine - administration & dosage</topic><topic>Berberine - analogs & derivatives</topic><topic>Berberine - pharmacology</topic><topic>Berberine - therapeutic use</topic><topic>Berberine Alkaloids - administration & dosage</topic><topic>Berberine Alkaloids - pharmacology</topic><topic>Berberine Alkaloids - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Candida - classification</topic><topic>Candida - drug effects</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Mahonia</topic><topic>Mahonia aquifolium</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacognosy. 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The results indicate a rational basis for the traditional use of Mahonia aquifolium for localized skin and mucosal infection therapy, as well as for the possible development of a preparation for supportive therapy of the diseases mentioned above. Copyright © 2004 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>15476315</pmid><doi>10.1002/ptr.1517</doi><tpages>3</tpages></addata></record> |
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| subjects | Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use antimicrobial activity Berberine - administration & dosage Berberine - analogs & derivatives Berberine - pharmacology Berberine - therapeutic use Berberine Alkaloids - administration & dosage Berberine Alkaloids - pharmacology Berberine Alkaloids - therapeutic use Biological and medical sciences Candida - classification Candida - drug effects General pharmacology Humans Mahonia Mahonia aquifolium Medical sciences Microbial Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Stems Propionibacterium acnes - classification Propionibacterium acnes - drug effects protoberberine alkaloids Staphylococcus - classification Staphylococcus - drug effects |
| title | Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids |
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