Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression

Hypoxia inducible factor 1alpha (HIF-1alpha) plays a central role in regulating tumor angiogenesis via its effects on vascular endothelial growth factor (VEGF) transcription, and its expression is regulated through proteasome-mediated degradation. Paradoxically, previous studies have shown that prot...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-03, Vol.69 (5), p.1836-1843
Hauptverfasser:	Zhu, Keyi, Chan, Waikin, Heymach, John, Wilkinson, Miles, McConkey, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - genetics Boronic Acids - pharmacology Bortezomib Cell Line, Tumor Down-Regulation Eukaryotic Initiation Factor-2 - physiology Gene Expression Regulation Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Lactones - pharmacology Phosphorylation Proteasome Endopeptidase Complex - physiology Proteasome Inhibitors Protein Biosynthesis Pyrazines - pharmacology Pyrroles - pharmacology RNA, Messenger - analysis Vascular Endothelial Growth Factor A - genetics
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