Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines

The intrinsic radioresistance of certain cancer cells may be closely associated with the constitutive activation of nuclear factor-kappa B (NF-kappaB) activity, which may lead to protection from apoptosis. Recently, nonapoptotic cell death, or autophagy, has been revealed as a novel response of canc...

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Veröffentlicht in:	Journal of neurosurgery 2009-03, Vol.110 (3), p.594-604
Hauptverfasser:	Tsuboi, Yoshifumi, Kurimoto, Masanori, Nagai, Shoichi, Hayakawa, Yumiko, Kamiyama, Hironaga, Hayashi, Nakamasa, Kitajima, Isao, Endo, Shunro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Apoptosis - physiology Autophagy - physiology Cell Line, Tumor Enzyme Inhibitors - pharmacology Glioma - pathology Humans Immunoblotting NF-kappa B - analysis NF-kappa B - drug effects Quinolines - pharmacology Radiation Tolerance
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