Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans

We used genome-wide RNA interference (RNAi) to identify genes that affect apoptosis in the C. elegans germ line. RNAi-mediated knockdown of 21 genes caused a moderate to strong increase in germ cell death. Genetic epistasis studies with these RNAi candidates showed that a large subset (16/21) requir...

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Veröffentlicht in:	Cell death and differentiation 2004-11, Vol.11 (11), p.1198-1203
Hauptverfasser:	Lettre, G, Kritikou, E A, Jaeggi, M, Calixto, A, Fraser, A G, Kamath, R S, Ahringer, J, Hengartner, M O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemistry Biomedical and Life Sciences Caenorhabditis elegans Cell Biology Cell Cycle Analysis Cell death DNA Damage DNA Repair Epistasis, Genetic Genes Genetic Techniques Genome Genomes Genotype Genotype & phenotype Germ Cells - metabolism Germ Cells - pathology Life Sciences Models, Biological Molecular biology Mutation original-paper Proteins RNA Interference Stem Cells Time Factors Tumor Suppressor Protein p53 - metabolism
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