Adipokines and the clinical laboratory: what to measure, when and how?
This review summarises current experimental adipokine investigations and will focus on some of the procedures and techniques that are currently important in the clinical research laboratory. The complexity of measuring adipokines is discussed and the relative success of the various applications in t...
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| Veröffentlicht in: | Journal of clinical pathology 2009-03, Vol.62 (3), p.206-211 |
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| container_title | Journal of clinical pathology |
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| creator | Hill, M J Kumar, S McTernan, P G |
| description | This review summarises current experimental adipokine investigations and will focus on some of the procedures and techniques that are currently important in the clinical research laboratory. The complexity of measuring adipokines is discussed and the relative success of the various applications in the transition from the laboratory to clinical diagnosis assessed. In addition, as new adipokines continue to emerge, this review will consider the direction research is taking at the cutting edge of novel adipokine discovery. Finally, how a more comprehensive understanding of the pathobiology related to adipokines may enhance innovative therapeutic strategies designed to attenuate the predicted explosion in obesity related diseases will be discussed. |
| doi_str_mv | 10.1136/jcp.2007.049171 |
| format | Article |
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The complexity of measuring adipokines is discussed and the relative success of the various applications in the transition from the laboratory to clinical diagnosis assessed. In addition, as new adipokines continue to emerge, this review will consider the direction research is taking at the cutting edge of novel adipokine discovery. Finally, how a more comprehensive understanding of the pathobiology related to adipokines may enhance innovative therapeutic strategies designed to attenuate the predicted explosion in obesity related diseases will be discussed.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2007.049171</identifier><identifier>PMID: 19251951</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adipocytes ; Adipokines - analysis ; Adipokines - physiology ; Adipose Tissue - chemistry ; Biological and medical sciences ; Biomarkers ; Biomarkers - analysis ; Body fat ; Cardiovascular disease ; Cytokines ; Diabetes ; Ethnicity ; Fasting ; Humans ; Influence ; Insulin ; Insulin resistance ; Investigative techniques, diagnostic techniques (general aspects) ; Laboratories ; Leptin - physiology ; Lipids ; Medical sciences ; Metabolic disorders ; Molecular weight ; Obesity ; Obesity - metabolism ; Pathology. 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The complexity of measuring adipokines is discussed and the relative success of the various applications in the transition from the laboratory to clinical diagnosis assessed. In addition, as new adipokines continue to emerge, this review will consider the direction research is taking at the cutting edge of novel adipokine discovery. Finally, how a more comprehensive understanding of the pathobiology related to adipokines may enhance innovative therapeutic strategies designed to attenuate the predicted explosion in obesity related diseases will be discussed.</description><subject>Adipocytes</subject><subject>Adipokines - analysis</subject><subject>Adipokines - physiology</subject><subject>Adipose Tissue - chemistry</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Body fat</subject><subject>Cardiovascular disease</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Ethnicity</subject><subject>Fasting</subject><subject>Humans</subject><subject>Influence</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laboratories</subject><subject>Leptin - physiology</subject><subject>Lipids</subject><subject>Medical sciences</subject><subject>Metabolic disorders</subject><subject>Molecular weight</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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| subjects | Adipocytes Adipokines - analysis Adipokines - physiology Adipose Tissue - chemistry Biological and medical sciences Biomarkers Biomarkers - analysis Body fat Cardiovascular disease Cytokines Diabetes Ethnicity Fasting Humans Influence Insulin Insulin resistance Investigative techniques, diagnostic techniques (general aspects) Laboratories Leptin - physiology Lipids Medical sciences Metabolic disorders Molecular weight Obesity Obesity - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Physiology Proteins Rodents |
| title | Adipokines and the clinical laboratory: what to measure, when and how? |
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