Constitutive expression of CXCL2/MIP-2 is restricted to a Gr-1high, CD11b+, CD62Lhigh subset of bone marrow derived granulocytes

CXCL2/macrophage inflammatory protein (MIP)-2 is an inducible murine chemokine involved in attraction of polymorphonuclear granulocytes to sites of infection. In comparison, its role as constitutive produced chemokine in mice is unclear. The present study aimed to specify the cellular source of cons...

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Veröffentlicht in:	International immunology 2004-11, Vol.16 (11), p.1675-1683
Hauptverfasser:	Matzer, Sigrid P., Rödel, Franz, Strieter, Robert M., Röllinghoff, Martin, Beuscher, H. Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BM bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - immunology CCL CC chemokine CD11b Antigen - immunology Cells, Cultured Chemokine CXCL2 chemokines CXCL CXC chemokine CXCR CXC chemokine receptor Female Gene Expression Regulation - genetics Gene Expression Regulation - immunology Granulocytes - immunology IP-10 inducible protein 10 KC platelet-derived growth factor-inducible chemokine KC L-Selectin - immunology LIX LPS-induced chemokine LTN lymphotactin Mice Mice, Inbred BALB C MIP macrophage inflammatory protein Monokines - biosynthesis Monokines - genetics neutrophils NRS normal rabbit serum PBL peripheral blood leukocytes Peyer's patches PP Peyer's patches RNA, Messenger - biosynthesis RNA, Messenger - genetics spleen XCL XCL chemokine
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