TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1

TORC2 is a major transcriptional coactivator for hepatic glucose production. Insulin impedes gluconeogenesis by inhibiting TORC2 via SIK2-dependent phosphorylation at Ser171. Interruption of this process greatly perturbs hepatic glucose metabolism, thus promoting hyperglycemia in rodents. Here, we s...

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Veröffentlicht in:	Cell metabolism 2009-03, Vol.9 (3), p.240-251
Hauptverfasser:	Ryu, Dongryeol, Oh, Kyoung-Jin, Jo, Hee-Yeon, Hedrick, Susan, Kim, Yo-Na, Hwang, Yu-Jin, Park, Tae-Sik, Han, Joong-Soo, Choi, Cheol Soo, Montminy, Marc, Koo, Seung-Hoi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Cells, Cultured Glucose Intolerance Hepatocytes - cytology Hepatocytes - metabolism HUMDISEASE Insulin - metabolism Insulin Resistance - physiology Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Inbred Strains Nuclear Proteins - genetics Nuclear Proteins - metabolism Oligonucleotide Array Sequence Analysis Phosphatidate Phosphatase Rats Rats, Sprague-Dawley Signal Transduction - physiology SIGNALING Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors Transcription, Genetic
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