The Epidermal Growth Factor-Like Growth Factor Amphiregulin Is Strongly Induced by the Adenosine 3′,5′-Monophosphate Pathway in Various Cell Types

We examined the cAMP-mediated regulation of the epidermal growth factor-like growth factor amphiregulin (AR) in T cells and observed a strong cAMP-induced up-regulation of AR mRNA in a time- and concentration-dependent manner independent of T cell activation. This regulation may be mediated in part...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-11, Vol.145 (11), p.5177-5184
Hauptverfasser:	Johansson, C. Christian, Yndestad, Arne, Enserink, Jorrit M, Ree, Anne H, Aukrust, Pål, Taskén, Kjetil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenylyl Cyclases - metabolism Adrenal Glands - cytology Amphiregulin Biological and medical sciences Breast Neoplasms Cell activation Cell proliferation Cyclic AMP Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Dinoprostone - metabolism EGF Family of Proteins Epidermal Growth Factor Female Forskolin Fundamental and applied biological sciences. Psychology Gene Expression - physiology Glycoproteins - genetics Glycoproteins - metabolism Growth factors Humans Immune system Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Kinases Lymphocytes Lymphocytes T Male Mammary gland MAP kinase MAP Kinase Signaling System - physiology Microenvironments Ovarian Neoplasms Paracrine signalling Phosphodiesterase inhibitors Phosphorylation Promoter Regions, Genetic - physiology Prostaglandin E2 Prostatic Neoplasms Protein folding Protein kinase A Proteins Regulatory sequences RNA, Messenger - metabolism Rolipram T-Lymphocytes - cytology T-Lymphocytes - metabolism Tumor cells Tumor Cells, Cultured Tumors Vertebrates: endocrinology
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