Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside

Congenital heart block is a serious cardiac manifestation of neonatal lupus erythematosus that is associated with exposure to maternal autoantibodies against components of the SSA/Ro–SSB/La ribonucleoprotein complex. This Review outlines our current hypothesis regarding the pathogenesis of this dise...

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Veröffentlicht in:	Nature clinical practice. Rheumatology 2009-03, Vol.5 (3), p.139-148
Hauptverfasser:	Buyon, Jill P, Clancy, Robert M, Friedman, Deborah M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Autoantibodies Autoantibodies - blood Cardiomyopathy Care and treatment Children & youth Congenital diseases Congenital heart disease Development and progression Disease susceptibility Electrocardiography Female Fetal Diseases - drug therapy Fetal Diseases - etiology Health aspects Heart Heart Block - congenital Heart Block - diagnosis Heart Block - therapy Heart Defects, Congenital - diagnosis Heart Defects, Congenital - etiology Heart Defects, Congenital - therapy Humans Immunoglobulin G - administration & dosage Infant, Newborn Infant, Newborn, Diseases - diagnosis Infant, Newborn, Diseases - etiology Infant, Newborn, Diseases - therapy Infusions, Intravenous Laboratories Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - immunology Medicine Medicine & Public Health Mothers Pregnancy review-article Rheumatology Ribonucleoproteins - immunology Risk Factors Womens health
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