A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes

Variants in the gene encoding NACHT leucine-rich-repeat protein 1 (NALP1), an important molecule in innate immunity, have recently been shown to confer risk for vitiligo and associated autoimmunity. We hypothesized that sequence variants in this gene may be involved in susceptibility to a wider spec...

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Veröffentlicht in:	Genes and immunity 2009-03, Vol.10 (2), p.120-124
Hauptverfasser:	Magitta, N F, Bøe Wolff, A S, Johansson, S, Skinningsrud, B, Lie, B A, Myhr, K-M, Undlien, D E, Joner, G, Njølstad, P R, Kvien, T K, Førre, Ø, Knappskog, P M, Husebye, E S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Addison Disease - genetics Addison's disease Adolescent Adult Aged Aged, 80 and over Apoptosis Apoptosis Regulatory Proteins - genetics Autoimmune diseases Autoimmunity Biomedical and Life Sciences Biomedicine Cancer Research Child Cohort Studies Cytokines Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - genetics Disease Endocrine disorders Female Gene Expression Genes Genetic aspects Hospitals Human Genetics Humans Immune system Immunity, Innate - genetics Immunology Innate immunity Lupus Male Medicine Middle Aged Multiple sclerosis Norway Open Reading Frames - genetics Organ Specificity - genetics original-article Patients Pediatrics Polymorphism Polymorphism, Single Nucleotide Rheumatoid arthritis Rheumatology Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Systemic lupus erythematosus Trends Type 1 diabetes Vitiligo
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