Suppression of bacterial biofilm formation by iron limitation

Suppression of bacterial biofilm formation by iron limitation

The concentration of iron that permits bacterial differentiation generally differs from that needed for vegetative cell growth. An undesirable manifestation of differentiation is biofilm formation. The process in some, but not all, bacterial systems requires a higher level of iron than is needed for...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Medical hypotheses 2004, Vol.63 (5), p.863-865
1. Verfasser: Weinberg, E.D.
Format: Artikel
Sprache:eng
Schlagworte:
Bacterial Adhesion - drug effects
Bacterial Adhesion - physiology
Bacterial Physiological Phenomena - drug effects
Biofilms - drug effects
Biofilms - growth & development
Humans
Iron - metabolism
Lactoferrin - pharmacology
Models, Biological
Transferrin - pharmacology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 865
container_issue 5
container_start_page 863
container_title Medical hypotheses
container_volume 63
creator Weinberg, E.D.
description The concentration of iron that permits bacterial differentiation generally differs from that needed for vegetative cell growth. An undesirable manifestation of differentiation is biofilm formation. The process in some, but not all, bacterial systems requires a higher level of iron than is needed for growth and it is suppressed by specific iron chelators. Human transferrin and lactoferrin, as well as at least six low molecular mass iron chelators, are now available for possible screening and clinical development as inhibitors of bacterial biofilm formation.
doi_str_mv 10.1016/j.mehy.2004.04.010
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66978834</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S030698770400283X</els_id><sourcerecordid>66978834</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-1665b127a15e37f0bf3b897709fcabb77ba3feb4e9460ebbf32d14e8fecb8f633</originalsourceid><addsrcrecordid>eNp9UMtKxDAUDaI44-gPuJCu3LUmTZukoAsZfMGAC3UdkvQGM7STmrRC_97WGXAnHDhwzwPuQeiS4Ixgwm62WQufY5ZjXGQzCD5CS1LSPM0558doiSlmaSU4X6CzGLcY46qg4hQtSFkIwRhZoru3oesCxOj8LvE20cr0EJxqEu28dU2bWB9a1c-yHhMXJm5c6_rf0zk6saqJcHHgFfp4fHhfP6eb16eX9f0mNbTM-5QwVmqSc0VKoNxibakWFee4skZpzblW1IIuoCoYBj3JeU0KEBaMFpZRukLX-94u-K8BYi9bFw00jdqBH6JkrOJC0GIy5nujCT7GAFZ2wbUqjJJgOY8mt3IeTc6jyRkET6GrQ_ugW6j_IoeVJsPt3gDTj98OgozGwc5A7QKYXtbe_df_Awavftw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66978834</pqid></control><display><type>article</type><title>Suppression of bacterial biofilm formation by iron limitation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Weinberg, E.D.</creator><creatorcontrib>Weinberg, E.D.</creatorcontrib><description>The concentration of iron that permits bacterial differentiation generally differs from that needed for vegetative cell growth. An undesirable manifestation of differentiation is biofilm formation. The process in some, but not all, bacterial systems requires a higher level of iron than is needed for growth and it is suppressed by specific iron chelators. Human transferrin and lactoferrin, as well as at least six low molecular mass iron chelators, are now available for possible screening and clinical development as inhibitors of bacterial biofilm formation.</description><identifier>ISSN: 0306-9877</identifier><identifier>EISSN: 1532-2777</identifier><identifier>DOI: 10.1016/j.mehy.2004.04.010</identifier><identifier>PMID: 15488661</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Bacterial Adhesion - drug effects ; Bacterial Adhesion - physiology ; Bacterial Physiological Phenomena - drug effects ; Biofilms - drug effects ; Biofilms - growth &amp; development ; Humans ; Iron - metabolism ; Lactoferrin - pharmacology ; Models, Biological ; Transferrin - pharmacology</subject><ispartof>Medical hypotheses, 2004, Vol.63 (5), p.863-865</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-1665b127a15e37f0bf3b897709fcabb77ba3feb4e9460ebbf32d14e8fecb8f633</citedby><cites>FETCH-LOGICAL-c352t-1665b127a15e37f0bf3b897709fcabb77ba3feb4e9460ebbf32d14e8fecb8f633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030698770400283X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15488661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weinberg, E.D.</creatorcontrib><title>Suppression of bacterial biofilm formation by iron limitation</title><title>Medical hypotheses</title><addtitle>Med Hypotheses</addtitle><description>The concentration of iron that permits bacterial differentiation generally differs from that needed for vegetative cell growth. An undesirable manifestation of differentiation is biofilm formation. The process in some, but not all, bacterial systems requires a higher level of iron than is needed for growth and it is suppressed by specific iron chelators. Human transferrin and lactoferrin, as well as at least six low molecular mass iron chelators, are now available for possible screening and clinical development as inhibitors of bacterial biofilm formation.</description><subject>Bacterial Adhesion - drug effects</subject><subject>Bacterial Adhesion - physiology</subject><subject>Bacterial Physiological Phenomena - drug effects</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth &amp; development</subject><subject>Humans</subject><subject>Iron - metabolism</subject><subject>Lactoferrin - pharmacology</subject><subject>Models, Biological</subject><subject>Transferrin - pharmacology</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtKxDAUDaI44-gPuJCu3LUmTZukoAsZfMGAC3UdkvQGM7STmrRC_97WGXAnHDhwzwPuQeiS4Ixgwm62WQufY5ZjXGQzCD5CS1LSPM0558doiSlmaSU4X6CzGLcY46qg4hQtSFkIwRhZoru3oesCxOj8LvE20cr0EJxqEu28dU2bWB9a1c-yHhMXJm5c6_rf0zk6saqJcHHgFfp4fHhfP6eb16eX9f0mNbTM-5QwVmqSc0VKoNxibakWFee4skZpzblW1IIuoCoYBj3JeU0KEBaMFpZRukLX-94u-K8BYi9bFw00jdqBH6JkrOJC0GIy5nujCT7GAFZ2wbUqjJJgOY8mt3IeTc6jyRkET6GrQ_ugW6j_IoeVJsPt3gDTj98OgozGwc5A7QKYXtbe_df_Awavftw</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Weinberg, E.D.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Suppression of bacterial biofilm formation by iron limitation</title><author>Weinberg, E.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-1665b127a15e37f0bf3b897709fcabb77ba3feb4e9460ebbf32d14e8fecb8f633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Bacterial Adhesion - drug effects</topic><topic>Bacterial Adhesion - physiology</topic><topic>Bacterial Physiological Phenomena - drug effects</topic><topic>Biofilms - drug effects</topic><topic>Biofilms - growth &amp; development</topic><topic>Humans</topic><topic>Iron - metabolism</topic><topic>Lactoferrin - pharmacology</topic><topic>Models, Biological</topic><topic>Transferrin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weinberg, E.D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weinberg, E.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of bacterial biofilm formation by iron limitation</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>2004</date><risdate>2004</risdate><volume>63</volume><issue>5</issue><spage>863</spage><epage>865</epage><pages>863-865</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>The concentration of iron that permits bacterial differentiation generally differs from that needed for vegetative cell growth. An undesirable manifestation of differentiation is biofilm formation. The process in some, but not all, bacterial systems requires a higher level of iron than is needed for growth and it is suppressed by specific iron chelators. Human transferrin and lactoferrin, as well as at least six low molecular mass iron chelators, are now available for possible screening and clinical development as inhibitors of bacterial biofilm formation.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>15488661</pmid><doi>10.1016/j.mehy.2004.04.010</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0306-9877
ispartof Medical hypotheses, 2004, Vol.63 (5), p.863-865
issn 0306-9877
1532-2777
language eng
recordid cdi_proquest_miscellaneous_66978834
source MEDLINE; Elsevier ScienceDirect Journals
subjects Bacterial Adhesion - drug effects
Bacterial Adhesion - physiology
Bacterial Physiological Phenomena - drug effects
Biofilms - drug effects
Biofilms - growth & development
Humans
Iron - metabolism
Lactoferrin - pharmacology
Models, Biological
Transferrin - pharmacology
title Suppression of bacterial biofilm formation by iron limitation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T21%3A17%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Suppression%20of%20bacterial%20biofilm%20formation%20by%20iron%20limitation&rft.jtitle=Medical%20hypotheses&rft.au=Weinberg,%20E.D.&rft.date=2004&rft.volume=63&rft.issue=5&rft.spage=863&rft.epage=865&rft.pages=863-865&rft.issn=0306-9877&rft.eissn=1532-2777&rft_id=info:doi/10.1016/j.mehy.2004.04.010&rft_dat=%3Cproquest_cross%3E66978834%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66978834&rft_id=info:pmid/15488661&rft_els_id=S030698770400283X&rfr_iscdi=true