Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo

The inhibitor of p38 mitogen‐activated protein kinase (MAPK) is of interest in the nonoperative treatment of periprosthetic osteolysis due to wear particles. Previous studies demonstrated that an oral p38 MAPK inhibitor did not suppress bone formation when given during the initial phase of tissue di...

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Veröffentlicht in:	Journal of Biomedical Materials Research Part B 2009-04, Vol.89A (1), p.117-123
Hauptverfasser:	Ma, T., Ren, P.-G., Larsen, D. M., Suenaga, E., Zilber, S., Genovese, M., Smith, R. L., Goodman, S. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal model Animals Biocompatible Materials - metabolism Bone and Bones - cytology Bone and Bones - drug effects Bone and Bones - metabolism bone ingrowth Enzyme Inhibitors - therapeutic use Humans Implants, Experimental Inflammation - drug therapy joint replacement Male Materials Testing p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38α MAPK inhibitor Polyethylene - immunology polyethylene particles Rabbits
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