Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes

Alpha(1)-Adrenergic receptors have been implicated in growth-promoting pathways. A microarray study of individual alpha(1)-adrenergic receptor subtypes (alpha(1A), alpha(1B), and alpha(1D)) expressed in Rat-1 fibroblasts revealed that epinephrine altered the transcription of several cell cycle regul...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-11, Vol.145 (11), p.5157-5167
Hauptverfasser:	Gonzalez-Cabrera, Pedro J, Shi, Ting, Yun, June, McCune, Dan F, Rorabaugh, Boyd R, Perez, Dianne M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Agonists - pharmacology Animals Cell Count Cell Cycle Proteins - metabolism Cell Division - physiology Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases - metabolism Epinephrine - pharmacology Fibroblasts - cytology Fibroblasts - physiology Flow Cytometry G1 Phase - drug effects G1 Phase - physiology Humans Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - physiology PC12 Cells Rats Receptors, Adrenergic, alpha-1 - genetics Receptors, Adrenergic, alpha-1 - metabolism S Phase - drug effects S Phase - physiology Transcription, Genetic - drug effects Tumor Suppressor Proteins - metabolism
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