Dynamic MR imaging: value of differentiating subtypes of peripheral small adenocarcinoma of the lung
Purpose: To determine the utility of dynamic magnetic resonance imaging (MRI) in the differential subtyping of small adenocarcinomas of the lung. Materials and methods: Twenty-nine pathologically diagnosed peripheral adenocarcinomas (less than 20 mm in diameter) underwent dynamic contrast-enhanced M...
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| Veröffentlicht in: | European journal of radiology 2004-11, Vol.52 (2), p.144-150 |
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| creator | Ohno, Yoshiharu Hatabu, Hiroto Takenaka, Daisuke Uematsu, Hidemasa Ohbayashi, Chiho Higashino, Takanori Nogami, Munenobu Yoshimura, Masahiro Fujii, Masahiko Sugimura, Kazuro |
| description | Purpose: To determine the utility of dynamic magnetic resonance imaging (MRI) in the differential subtyping of small adenocarcinomas of the lung.
Materials and methods: Twenty-nine pathologically diagnosed peripheral adenocarcinomas (less than 20
mm in diameter) underwent dynamic contrast-enhanced MRI. Maximum relative enhancement ratio, slope of enhancement, and corrected start time of enhancement were calculated from signal intensity–time curve of pulmonary lesion for each subject, and were statistically compared among bronchioloalveolar carcinoma (BAC) group (7 cases), mixed BAC group (10 cases), and adenocarcinoma group (12 cases).
Results: Maximum relative enhancement ratio (
P |
| doi_str_mv | 10.1016/j.ejrad.2004.01.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66978101</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0720048X04000397</els_id><sourcerecordid>66978101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-bd0757b2f79e3a182da6609dd2d307916af61958e418a2af4c42aec88175eb8f3</originalsourceid><addsrcrecordid>eNp9kE2LFDEQhoMo7rj6CwTJyVuPlfRH0oIH2Q8VVhYWBW-hOqnMZugvk-6F-fdmnAFvQkEd6nmrqIextwK2AkTzYb-lfUS3lQDVFkSu-hnbCK1koZRUz9kGlIQCKv3rgr1KaQ8AddXKl-xC1JVuQYkNc9eHEYdg-fcHHgbchXH3kT9hvxKfPHfBe4o0LgGXPOFp7ZbDTOk4mymG-ZEi9jwN2PccHY2TxWjDOA14RJZH4v067l6zFx77RG_O_ZL9vL35cfW1uLv_8u3q811hK1kuRedA1aqTXrVUotDSYdNA65x0JahWNOgb0daaKqFRoq9yDMlqLVRNnfblJXt_2jvH6fdKaTFDSJb6Hkea1mSaplU6u8tgeQJtnFKK5M0c8_fxYASYo1yzN3_lmqNcAyJXnVPvzuvXbiD3L3O2mYFPJ4Dyk0-Bokk20GjJhUh2MW4K_z3wB-z-jPA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66978101</pqid></control><display><type>article</type><title>Dynamic MR imaging: value of differentiating subtypes of peripheral small adenocarcinoma of the lung</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ohno, Yoshiharu ; Hatabu, Hiroto ; Takenaka, Daisuke ; Uematsu, Hidemasa ; Ohbayashi, Chiho ; Higashino, Takanori ; Nogami, Munenobu ; Yoshimura, Masahiro ; Fujii, Masahiko ; Sugimura, Kazuro</creator><creatorcontrib>Ohno, Yoshiharu ; Hatabu, Hiroto ; Takenaka, Daisuke ; Uematsu, Hidemasa ; Ohbayashi, Chiho ; Higashino, Takanori ; Nogami, Munenobu ; Yoshimura, Masahiro ; Fujii, Masahiko ; Sugimura, Kazuro</creatorcontrib><description>Purpose: To determine the utility of dynamic magnetic resonance imaging (MRI) in the differential subtyping of small adenocarcinomas of the lung.
Materials and methods: Twenty-nine pathologically diagnosed peripheral adenocarcinomas (less than 20
mm in diameter) underwent dynamic contrast-enhanced MRI. Maximum relative enhancement ratio, slope of enhancement, and corrected start time of enhancement were calculated from signal intensity–time curve of pulmonary lesion for each subject, and were statistically compared among bronchioloalveolar carcinoma (BAC) group (7 cases), mixed BAC group (10 cases), and adenocarcinoma group (12 cases).
Results: Maximum relative enhancement ratio (
P<0.001) and slope of enhancement (
P<0.001) of BAC group were significantly higher than those of mixed BAC and adenocarcinoma groups. Start times of BAC group were significantly earlier than those of mixed BAC (
P=0.0001) and adenocarcinoma groups (
P<0.0001). Adapting the thresholds values of MR indexes from the positive tests, sensitivity, specificity, positive predictive value, negative predictive value and accuracy for differentiating BAC from other subtypes were 85.7, 100.0, 100.0, 95.7, and 96.6%, respectively.
Conclusions: Dynamic MRI is useful for differentiating subtypes of small peripheral adenocarcinoma.</description><identifier>ISSN: 0720-048X</identifier><identifier>EISSN: 1872-7727</identifier><identifier>DOI: 10.1016/j.ejrad.2004.01.015</identifier><identifier>PMID: 15489071</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adenocarcinoma - classification ; Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Dynamic MR ; Female ; Humans ; Lung ; Lung cancer ; Lung neoplasms ; Lung Neoplasms - classification ; Lung Neoplasms - pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged</subject><ispartof>European journal of radiology, 2004-11, Vol.52 (2), p.144-150</ispartof><rights>2004 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-bd0757b2f79e3a182da6609dd2d307916af61958e418a2af4c42aec88175eb8f3</citedby><cites>FETCH-LOGICAL-c423t-bd0757b2f79e3a182da6609dd2d307916af61958e418a2af4c42aec88175eb8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0720048X04000397$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15489071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohno, Yoshiharu</creatorcontrib><creatorcontrib>Hatabu, Hiroto</creatorcontrib><creatorcontrib>Takenaka, Daisuke</creatorcontrib><creatorcontrib>Uematsu, Hidemasa</creatorcontrib><creatorcontrib>Ohbayashi, Chiho</creatorcontrib><creatorcontrib>Higashino, Takanori</creatorcontrib><creatorcontrib>Nogami, Munenobu</creatorcontrib><creatorcontrib>Yoshimura, Masahiro</creatorcontrib><creatorcontrib>Fujii, Masahiko</creatorcontrib><creatorcontrib>Sugimura, Kazuro</creatorcontrib><title>Dynamic MR imaging: value of differentiating subtypes of peripheral small adenocarcinoma of the lung</title><title>European journal of radiology</title><addtitle>Eur J Radiol</addtitle><description>Purpose: To determine the utility of dynamic magnetic resonance imaging (MRI) in the differential subtyping of small adenocarcinomas of the lung.
Materials and methods: Twenty-nine pathologically diagnosed peripheral adenocarcinomas (less than 20
mm in diameter) underwent dynamic contrast-enhanced MRI. Maximum relative enhancement ratio, slope of enhancement, and corrected start time of enhancement were calculated from signal intensity–time curve of pulmonary lesion for each subject, and were statistically compared among bronchioloalveolar carcinoma (BAC) group (7 cases), mixed BAC group (10 cases), and adenocarcinoma group (12 cases).
Results: Maximum relative enhancement ratio (
P<0.001) and slope of enhancement (
P<0.001) of BAC group were significantly higher than those of mixed BAC and adenocarcinoma groups. Start times of BAC group were significantly earlier than those of mixed BAC (
P=0.0001) and adenocarcinoma groups (
P<0.0001). Adapting the thresholds values of MR indexes from the positive tests, sensitivity, specificity, positive predictive value, negative predictive value and accuracy for differentiating BAC from other subtypes were 85.7, 100.0, 100.0, 95.7, and 96.6%, respectively.
Conclusions: Dynamic MRI is useful for differentiating subtypes of small peripheral adenocarcinoma.</description><subject>Adenocarcinoma - classification</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Dynamic MR</subject><subject>Female</subject><subject>Humans</subject><subject>Lung</subject><subject>Lung cancer</subject><subject>Lung neoplasms</subject><subject>Lung Neoplasms - classification</subject><subject>Lung Neoplasms - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><issn>0720-048X</issn><issn>1872-7727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo7rj6CwTJyVuPlfRH0oIH2Q8VVhYWBW-hOqnMZugvk-6F-fdmnAFvQkEd6nmrqIextwK2AkTzYb-lfUS3lQDVFkSu-hnbCK1koZRUz9kGlIQCKv3rgr1KaQ8AddXKl-xC1JVuQYkNc9eHEYdg-fcHHgbchXH3kT9hvxKfPHfBe4o0LgGXPOFp7ZbDTOk4mymG-ZEi9jwN2PccHY2TxWjDOA14RJZH4v067l6zFx77RG_O_ZL9vL35cfW1uLv_8u3q811hK1kuRedA1aqTXrVUotDSYdNA65x0JahWNOgb0daaKqFRoq9yDMlqLVRNnfblJXt_2jvH6fdKaTFDSJb6Hkea1mSaplU6u8tgeQJtnFKK5M0c8_fxYASYo1yzN3_lmqNcAyJXnVPvzuvXbiD3L3O2mYFPJ4Dyk0-Bokk20GjJhUh2MW4K_z3wB-z-jPA</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Ohno, Yoshiharu</creator><creator>Hatabu, Hiroto</creator><creator>Takenaka, Daisuke</creator><creator>Uematsu, Hidemasa</creator><creator>Ohbayashi, Chiho</creator><creator>Higashino, Takanori</creator><creator>Nogami, Munenobu</creator><creator>Yoshimura, Masahiro</creator><creator>Fujii, Masahiko</creator><creator>Sugimura, Kazuro</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041101</creationdate><title>Dynamic MR imaging: value of differentiating subtypes of peripheral small adenocarcinoma of the lung</title><author>Ohno, Yoshiharu ; Hatabu, Hiroto ; Takenaka, Daisuke ; Uematsu, Hidemasa ; Ohbayashi, Chiho ; Higashino, Takanori ; Nogami, Munenobu ; Yoshimura, Masahiro ; Fujii, Masahiko ; Sugimura, Kazuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-bd0757b2f79e3a182da6609dd2d307916af61958e418a2af4c42aec88175eb8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenocarcinoma - classification</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Dynamic MR</topic><topic>Female</topic><topic>Humans</topic><topic>Lung</topic><topic>Lung cancer</topic><topic>Lung neoplasms</topic><topic>Lung Neoplasms - classification</topic><topic>Lung Neoplasms - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohno, Yoshiharu</creatorcontrib><creatorcontrib>Hatabu, Hiroto</creatorcontrib><creatorcontrib>Takenaka, Daisuke</creatorcontrib><creatorcontrib>Uematsu, Hidemasa</creatorcontrib><creatorcontrib>Ohbayashi, Chiho</creatorcontrib><creatorcontrib>Higashino, Takanori</creatorcontrib><creatorcontrib>Nogami, Munenobu</creatorcontrib><creatorcontrib>Yoshimura, Masahiro</creatorcontrib><creatorcontrib>Fujii, Masahiko</creatorcontrib><creatorcontrib>Sugimura, Kazuro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohno, Yoshiharu</au><au>Hatabu, Hiroto</au><au>Takenaka, Daisuke</au><au>Uematsu, Hidemasa</au><au>Ohbayashi, Chiho</au><au>Higashino, Takanori</au><au>Nogami, Munenobu</au><au>Yoshimura, Masahiro</au><au>Fujii, Masahiko</au><au>Sugimura, Kazuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic MR imaging: value of differentiating subtypes of peripheral small adenocarcinoma of the lung</atitle><jtitle>European journal of radiology</jtitle><addtitle>Eur J Radiol</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>52</volume><issue>2</issue><spage>144</spage><epage>150</epage><pages>144-150</pages><issn>0720-048X</issn><eissn>1872-7727</eissn><abstract>Purpose: To determine the utility of dynamic magnetic resonance imaging (MRI) in the differential subtyping of small adenocarcinomas of the lung.
Materials and methods: Twenty-nine pathologically diagnosed peripheral adenocarcinomas (less than 20
mm in diameter) underwent dynamic contrast-enhanced MRI. Maximum relative enhancement ratio, slope of enhancement, and corrected start time of enhancement were calculated from signal intensity–time curve of pulmonary lesion for each subject, and were statistically compared among bronchioloalveolar carcinoma (BAC) group (7 cases), mixed BAC group (10 cases), and adenocarcinoma group (12 cases).
Results: Maximum relative enhancement ratio (
P<0.001) and slope of enhancement (
P<0.001) of BAC group were significantly higher than those of mixed BAC and adenocarcinoma groups. Start times of BAC group were significantly earlier than those of mixed BAC (
P=0.0001) and adenocarcinoma groups (
P<0.0001). Adapting the thresholds values of MR indexes from the positive tests, sensitivity, specificity, positive predictive value, negative predictive value and accuracy for differentiating BAC from other subtypes were 85.7, 100.0, 100.0, 95.7, and 96.6%, respectively.
Conclusions: Dynamic MRI is useful for differentiating subtypes of small peripheral adenocarcinoma.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15489071</pmid><doi>10.1016/j.ejrad.2004.01.015</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma - classification Adenocarcinoma - pathology Adult Aged Aged, 80 and over Dynamic MR Female Humans Lung Lung cancer Lung neoplasms Lung Neoplasms - classification Lung Neoplasms - pathology Magnetic Resonance Imaging Male Middle Aged |
| title | Dynamic MR imaging: value of differentiating subtypes of peripheral small adenocarcinoma of the lung |
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