Leukemia inhibitory factor-transfected embryonic fibroblasts and vascular endothelial growth factor successfully improve the skin substitute wound healing by increasing angiogenesis and matrix production

Background and objective : The combined application of cytokines on embryonic fibroblasts and dermal substitute were studied for optimal skin defect coverage. The mechanism of combined treatment of leukemia inhibitory factor (LIF)-transfected embryonic fibroblasts and vascular endothelial growth fac...

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Veröffentlicht in:	Journal of dermatological science 2004-10, Vol.36 (1), p.11-23
Hauptverfasser:	Akita, Sadanori, Daian, Takahiro, Ishihara, Hiroshi, Fujii, Tohru, Akino, Kozo
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Angiogenesis Animals Antigens, CD34 - biosynthesis Blotting, Western Cell Proliferation Collagen - metabolism Cutaneous regeneration DNA, Complementary - metabolism Extracellular Matrix - metabolism Fibroblasts - metabolism Fibronectins - metabolism Immunohistochemistry Interleukin-6 - genetics Leukemia Inhibitory Factor Male MAP Kinase Signaling System Mice Mice, Inbred BALB C Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neovascularization, Pathologic Phosphorylation Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism Signal Transduction Skin - metabolism Time Factors Transfection Vascular Endothelial Growth Factor A - metabolism Wound healing
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