The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta2Glycoprotein I antibodies

The anti-phospholipid syndrome (APS) is characterized by thrombosis and the presence of anti-phospholipid antibodies (aPL). Tissue factor (TF), the major initiator of the coagulation system, is induced on monocytes by aPL in vitro, explaining, in part, the pathophysiology in this syndrome. However,...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International immunology 2004-11, Vol.16 (11), p.1633-1641
Hauptverfasser:	Bohgaki, Miyuki, Atsumi, Tatsuya, Yamashita, Yumi, Yasuda, Shinsuke, Sakai, Yoshie, Furusaki, Akira, Bohgaki, Toshiyuki, Amengual, Olga, Amasaki, Yoshiharu, Koike, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology beta 2-Glycoprotein I Cells, Cultured Gene Expression Regulation - genetics Gene Expression Regulation - immunology Glycoproteins - immunology Humans MAP Kinase Signaling System - immunology Monocytes - immunology p38 Mitogen-Activated Protein Kinases - immunology RNA, Messenger - biosynthesis RNA, Messenger - genetics Thromboplastin - biosynthesis Thromboplastin - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!