Visual recovery after radiation therapy for bilateral subfoveal acute myelogenous leukemia (AML)

Present a case of bilateral foveal acute myelogenous leukemic tumors that responded to radiation therapy. Case report. A patient was diagnosed with bilateral subfoveal infiltration of known systemic acute myelogenous leukemia. He received a standard induction chemotherapy, followed by consolidation...

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Veröffentlicht in:American journal of ophthalmology 2004-10, Vol.138 (4), p.659-662
Hauptverfasser: Finger, Paul T., Pro, Michael J., Schneider, Susan, Kurli, Madhavi, Shapira, Ilan, Hu, Kenneth
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container_issue 4
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container_title American journal of ophthalmology
container_volume 138
creator Finger, Paul T.
Pro, Michael J.
Schneider, Susan
Kurli, Madhavi
Shapira, Ilan
Hu, Kenneth
description Present a case of bilateral foveal acute myelogenous leukemic tumors that responded to radiation therapy. Case report. A patient was diagnosed with bilateral subfoveal infiltration of known systemic acute myelogenous leukemia. He received a standard induction chemotherapy, followed by consolidation therapy for his systemic leukemia. However, despite a complete marrow response, the intraocular tumors did not regress. Therefore, he was given low dose (1950-cGy) ocular external beam radiation therapy. One course of systemic cytarabine chemotherapy failed to control the subfoveal tumors, leaving the patient at risk for permanent vision loss. In contrast, external beam radiation therapy improved his vision from 20/60 in his right eye to 20/20 and from 20/70 in his left eye to 20/25. Although systemic chemotherapy can be used to treat intraocular metastasis, external beam radiation may provide more prompt resolution of vision-threatening tumors.
doi_str_mv 10.1016/j.ajo.2004.04.047
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subjects Adult
Biological and medical sciences
Bone marrow
Chemotherapy
Diseases of the eye
Fluorescein Angiography
Hematologic and hematopoietic diseases
Humans
Leukemia
Leukemia, Myeloid, Acute - physiopathology
Leukemia, Myeloid, Acute - radiotherapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Radiation therapy
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Recovery of Function - physiology
Retinal Neoplasms - physiopathology
Retinal Neoplasms - radiotherapy
Tumors
Visual Acuity - physiology
title Visual recovery after radiation therapy for bilateral subfoveal acute myelogenous leukemia (AML)
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