Stability of Cough Linctus (Streptol) Formulated from Named Medicinal Plant Extracts
Extracts of named medicinal herbs (Garcinia kola, Zingiber oificinale, Aframonum melequeta and Ocimum viride) were formulated into an antitussive preparation to alleviate cough. Some physical properties of the cough syrup formulation evaluated were: specific gravity, pH, viscosity, content uniformit...
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| Veröffentlicht in: | Chemical & Pharmaceutical Bulletin 2009/03/01, Vol.57(3), pp.229-232 |
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| container_title | Chemical & Pharmaceutical Bulletin |
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| creator | Iwu, Maurice Okunji, Christopher Tchimene, Michel Anele, Ngozi Chah, Kennedy Osonwa, Uduma Akpa, Paul Achile Onunkwo, Godswill Chukwunweike |
| description | Extracts of named medicinal herbs (Garcinia kola, Zingiber oificinale, Aframonum melequeta and Ocimum viride) were formulated into an antitussive preparation to alleviate cough. Some physical properties of the cough syrup formulation evaluated were: specific gravity, pH, viscosity, content uniformity, and shelf life. The specific gravity and viscosity of the formulations were stable on storage, with glycerin-based formulations having higher values. The pH of the formulation varied from 4.2 to 5.3 and was also stable on storage. Glycerin-based formulations had lower pH values. The total flavonoids content of Streptol was calculated based on GB1 and found to be 46 mg. The estimated shelf life of the Streptol cough syrup was 4.5 years. |
| doi_str_mv | 10.1248/cpb.57.229 |
| format | Article |
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Some physical properties of the cough syrup formulation evaluated were: specific gravity, pH, viscosity, content uniformity, and shelf life. The specific gravity and viscosity of the formulations were stable on storage, with glycerin-based formulations having higher values. The pH of the formulation varied from 4.2 to 5.3 and was also stable on storage. Glycerin-based formulations had lower pH values. The total flavonoids content of Streptol was calculated based on GB1 and found to be 46 mg. The estimated shelf life of the Streptol cough syrup was 4.5 years.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.57.229</identifier><identifier>PMID: 19252311</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Antitussive Agents - chemistry ; Antitussive Agents - pharmacology ; Chemistry, Pharmaceutical ; content uniformity ; Flavonoids - chemistry ; Glycerol - chemistry ; Half-Life ; Hydrogen-Ion Concentration ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; shelf life ; Sorbitol - chemistry ; Specific Gravity ; Streptol ; Temperature ; Viscosity</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2009/03/01, Vol.57(3), pp.229-232</ispartof><rights>2009 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-76f293cbc6a822130937e0bbf7fbdb58025942e6d71954faeabde089195f492c3</citedby><cites>FETCH-LOGICAL-c685t-76f293cbc6a822130937e0bbf7fbdb58025942e6d71954faeabde089195f492c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19252311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwu, Maurice</creatorcontrib><creatorcontrib>Okunji, Christopher</creatorcontrib><creatorcontrib>Tchimene, Michel</creatorcontrib><creatorcontrib>Anele, Ngozi</creatorcontrib><creatorcontrib>Chah, Kennedy</creatorcontrib><creatorcontrib>Osonwa, Uduma</creatorcontrib><creatorcontrib>Akpa, Paul Achile</creatorcontrib><creatorcontrib>Onunkwo, Godswill Chukwunweike</creatorcontrib><creatorcontrib>University of Nigeria; Nsukka</creatorcontrib><creatorcontrib>cFaculty of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Faculty of Veterinary Medicine</creatorcontrib><creatorcontrib>Nigeria</creatorcontrib><creatorcontrib>University of Nigeria</creatorcontrib><creatorcontrib>aInternational Centre for Ethno Medicine and Drug Discovery (InterCEDD; Nsukka</creatorcontrib><creatorcontrib>Enugu State</creatorcontrib><creatorcontrib>bDepartment of Veterinary Microbiology</creatorcontrib><title>Stability of Cough Linctus (Streptol) Formulated from Named Medicinal Plant Extracts</title><title>Chemical & Pharmaceutical Bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Extracts of named medicinal herbs (Garcinia kola, Zingiber oificinale, Aframonum melequeta and Ocimum viride) were formulated into an antitussive preparation to alleviate cough. Some physical properties of the cough syrup formulation evaluated were: specific gravity, pH, viscosity, content uniformity, and shelf life. The specific gravity and viscosity of the formulations were stable on storage, with glycerin-based formulations having higher values. The pH of the formulation varied from 4.2 to 5.3 and was also stable on storage. Glycerin-based formulations had lower pH values. The total flavonoids content of Streptol was calculated based on GB1 and found to be 46 mg. The estimated shelf life of the Streptol cough syrup was 4.5 years.</description><subject>Antitussive Agents - chemistry</subject><subject>Antitussive Agents - pharmacology</subject><subject>Chemistry, Pharmaceutical</subject><subject>content uniformity</subject><subject>Flavonoids - chemistry</subject><subject>Glycerol - chemistry</subject><subject>Half-Life</subject><subject>Hydrogen-Ion Concentration</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal - chemistry</subject><subject>shelf life</subject><subject>Sorbitol - chemistry</subject><subject>Specific Gravity</subject><subject>Streptol</subject><subject>Temperature</subject><subject>Viscosity</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV2LEzEUhoMobl298QdIQBAVpuZjMplciZStCvUDdr0OSSbZpmQmNcmA--9NmboL3pyTQ5685-UNAC8xWmPS9h_MUa8ZXxMiHoEVpi1vGCH0MVghhERDaEcvwLOcDwgRhjh9Ci6wIIxQjFfg5roo7YMvdzA6uInz7R7u_GTKnOHb65LsscTwDm5jGuegih2gS3GE39VYj9_s4I2fVIA_g5oKvPpTkjIlPwdPnArZvjj3S_Bre3Wz-dLsfnz-uvm0a0zXs9LwzhFBjTad6gnBFAnKLdLacacHzfpqV7TEdgPHgrVOWaUHi3pRJ9cKYugleLPoHlP8Pdtc5OizsaGasXHOsusEbznmFXz9H3iIc6rGs8Rth1rSMdZX6v1CmRRzTtbJY_KjSncSI3lKWtakJeOyJl3hV2fJWdcsHtBztBXYLsB4SkmFOAU_2YfFJnOzt6OXpP6SRIhxRGvDElX5WijBPRXotOnjInTIRd3a-00qFW-C_WeKLuX0-P5mr5K0E_0LjXmk_g</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Iwu, Maurice</creator><creator>Okunji, Christopher</creator><creator>Tchimene, Michel</creator><creator>Anele, Ngozi</creator><creator>Chah, Kennedy</creator><creator>Osonwa, Uduma</creator><creator>Akpa, Paul Achile</creator><creator>Onunkwo, Godswill Chukwunweike</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Stability of Cough Linctus (Streptol) Formulated from Named Medicinal Plant Extracts</title><author>Iwu, Maurice ; 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Pharm. Bull.</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>57</volume><issue>3</issue><spage>229</spage><epage>232</epage><pages>229-232</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Extracts of named medicinal herbs (Garcinia kola, Zingiber oificinale, Aframonum melequeta and Ocimum viride) were formulated into an antitussive preparation to alleviate cough. Some physical properties of the cough syrup formulation evaluated were: specific gravity, pH, viscosity, content uniformity, and shelf life. The specific gravity and viscosity of the formulations were stable on storage, with glycerin-based formulations having higher values. The pH of the formulation varied from 4.2 to 5.3 and was also stable on storage. Glycerin-based formulations had lower pH values. The total flavonoids content of Streptol was calculated based on GB1 and found to be 46 mg. 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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Antitussive Agents - chemistry Antitussive Agents - pharmacology Chemistry, Pharmaceutical content uniformity Flavonoids - chemistry Glycerol - chemistry Half-Life Hydrogen-Ion Concentration Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry shelf life Sorbitol - chemistry Specific Gravity Streptol Temperature Viscosity |
| title | Stability of Cough Linctus (Streptol) Formulated from Named Medicinal Plant Extracts |
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