Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-β/Smad3-mediated transcriptional activation

Transforming growth factor- β (TGF- β ) is a pleiotropic cytokine implicated as a pathogenic mediator in various liver diseases. Enhanced TGF- β production and lack of TGF- β responses are often observed during hepatitis C virus (HCV) infection. In this study, we demonstrate that TGF- β -mediated tr...

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Veröffentlicht in:	Oncogene 2004-10, Vol.23 (47), p.7821-7838
Hauptverfasser:	Cheng, Pei-Lin, Chang, Meng-Hsiung, Chao, Chi-Hong, Lee, Yan-Hwa Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Carcinoma, Hepatocellular Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclin-dependent kinase inhibitor p21 Cytokines Deoxyribonucleic acid DNA DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology G1 phase G1 Phase - drug effects G1 Phase - physiology Hepacivirus Hepatitis C Hepatitis C virus Homology Human Genetics Human viral diseases Humans Infectious diseases Internal Medicine Liver diseases Liver Neoplasms Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Nuclear transport Oncology original-paper Plasmids - genetics Polymerase Chain Reaction Proteins Recombinant Fusion Proteins - metabolism Smad3 Protein Sp1 protein Trans-Activators - metabolism Transcription activation Transcription Factors - metabolism Transcriptional Activation Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Transforming growth factor-b Viral Core Proteins - metabolism Viral diseases Viral diseases of the digestive system Viral hepatitis Viral Nonstructural Proteins - metabolism Viral Proteins - metabolism
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