Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies

Purpose The impact of ions on protein aggregation remains poorly understood. We explored the role of ionic strength and ion identity on the temperature- and agitation-induced aggregation of antibodies. Methods Stability studies were used to determine the influence of monovalent Hofmeister anions and...

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Veröffentlicht in:	Pharmaceutical research 2009-04, Vol.26 (4), p.903-913
Hauptverfasser:	Fesinmeyer, R. Matthew, Hogan, Sabine, Saluja, Atul, Brych, Stephen R, Kras, Eva, Narhi, Linda O, Brems, David N, Gokarn, Yatin R
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation Antibodies, Monoclonal - chemistry Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemical bonds Drug Storage Excipients - chemistry General pharmacology Hofmeister effect Hot Temperature Immunoglobulin G - chemistry Ions Medical Law Medical sciences Models, Chemical monoclonal antibody Osmolar Concentration Pharmaceutical technology. Pharmaceutical industry Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Protein Conformation Protein Denaturation Protein Folding Protein Stability Proteins reduced valence Research Paper Solubility Technology, Pharmaceutical - methods Temperature Time Factors Transition Temperature Water - chemistry
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