Preconditioning with prolonged normobaric hyperoxia induces ischemic tolerance partly by upregulation of antioxidant enzymes in rat brain tissue

Abstract Recent studies suggest that normobaric hyperoxia (HO) results in brain ischemic tolerance (BIT), reducing ischemic brain injury. We have attempted to determine the time course of HO-induced upregulation of antioxidant enzymes. Rodents comprised five groups, breathing room air (RA; O2 = 21%)...

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Veröffentlicht in:	Brain research 2009-03, Vol.1260, p.47-54
1. Verfasser:	Bigdeli, Mohammad Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antioxidants - metabolism Biological and medical sciences Brain - blood supply Brain - enzymology Brain - pathology Brain ischemia tolerance Catalase Catalase - metabolism Glutathione peroxidase Glutathione Peroxidase - metabolism Glutathione reductase Glutathione Reductase - metabolism Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Ischemic Preconditioning Laser-Doppler Flowmetry Male Medical sciences Motor Activity Neurology Neuroprotection Normobaric hyperoxia Oxygen - metabolism Rats Rats, Sprague-Dawley Reperfusion Injury - prevention & control Stroke Superoxide dismutase Superoxide Dismutase - metabolism Vascular diseases and vascular malformations of the nervous system
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