Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model

Tumour growth and spread of tumour cells requires angiogenesis. Incipient angiogenesis is not induced by tumour cell hypoxia but probably by proangiogenic factors. During growth tumours depend on a further induction of vascular development for adequate oxygen and nutrient supply. If the oxygen suppl...

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Veröffentlicht in:	Microvascular research 2009-03, Vol.77 (2), p.96-103
Hauptverfasser:	Hendriksen, E.M., Span, P.N., Schuuring, J., Peters, J.P.W., Sweep, F.C.G.J., van der Kogel, A.J., Bussink, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Blood Vessels - pathology Cell Line, Tumor Enzyme-Linked Immunosorbent Assay Glioblastoma - blood supply Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme HIF-1α Humans Hypoxia Hypoxia - metabolism Hypoxia - pathology Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Mice, Nude Microenvironment Neoplasm Transplantation Neovascularization, Pathologic - metabolism Pimonidazole Transplantation, Heterologous Vascular Endothelial Growth Factor A - metabolism VEGF
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