Metabolism of protocatechuic acid influences fatty acid oxidation in rat heart: New anti-angina mechanism implication

Protocatechuic acid (PA), a structurally typical phenolic acid in danshen, shows anti-angina efficacy. But until now, besides scavenging of oxygen free radicals, the understanding of its anti-angina mechanism has been limited. In our study, based on a novel metabolic route of PA identified in rat he...

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Veröffentlicht in:	Biochemical pharmacology 2009-03, Vol.77 (6), p.1096-1104
Hauptverfasser:	Cao, Yan-guang, Zhang, Lin, Ma, Chen, Chang, Bo-bo, Chen, Yuan-Cheng, Tang, Yi-qun, Liu, Xiao-dong, Liu, Xiao-quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angina, Unstable - metabolism Angina, Unstable - prevention & control Animals Anti-angina Biological and medical sciences Cardiology. Vascular system Coronary heart disease Dose-Response Relationship, Drug Fatty acid oxidation Fatty Acids - analysis Fatty Acids - metabolism Heart Heart - physiology Hydroxybenzoates - metabolism In Vitro Techniques Male Medical sciences Metabolism Oxidation-Reduction Pharmacology. Drug treatments Protocatechuic acid Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
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