Growth Patterns and the Risk of Breast Cancer in Women
In this study, associations between breast cancer and patterns of growth during childhood were analyzed in the school health records of 117,415 Danish women. High birth weight, a young age at peak growth, and high stature and low body-mass index at 14 years of age were all independent risk factors f...
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| Veröffentlicht in: | The New England journal of medicine 2004-10, Vol.351 (16), p.1619-1626 |
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| container_title | The New England journal of medicine |
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| creator | Ahlgren, Martin Melbye, Mads Wohlfahrt, Jan Sørensen, Thorkild I. A |
| description | In this study, associations between breast cancer and patterns of growth during childhood were analyzed in the school health records of 117,415 Danish women. High birth weight, a young age at peak growth, and high stature and low body-mass index at 14 years of age were all independent risk factors for breast cancer in adulthood. The mechanisms of these associations are unknown, but the data indicate that growth during childhood influences the risk of breast cancer during adult life.
Patterns of growth analyzed in the school health records of 117,415 Danish women indicate that growth during childhood influences the risk of breast cancer.
Most studies of body size and the risk of breast cancer have shown that tall women have an increased risk of breast cancer regardless of menopausal status,
1
whereas obese women have a reduced risk of breast cancer before menopause but an increased risk after menopause.
2
The extent to which these associations in adults reflect growth patterns in early life is unknown. A better understanding of the association between early growth patterns and the risk of breast cancer could improve our knowledge of the mechanisms of the disease and could be important for prevention.
We explored possible associations among birth weight, . . . |
| doi_str_mv | 10.1056/NEJMoa040576 |
| format | Article |
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Patterns of growth analyzed in the school health records of 117,415 Danish women indicate that growth during childhood influences the risk of breast cancer.
Most studies of body size and the risk of breast cancer have shown that tall women have an increased risk of breast cancer regardless of menopausal status,
1
whereas obese women have a reduced risk of breast cancer before menopause but an increased risk after menopause.
2
The extent to which these associations in adults reflect growth patterns in early life is unknown. A better understanding of the association between early growth patterns and the risk of breast cancer could improve our knowledge of the mechanisms of the disease and could be important for prevention.
We explored possible associations among birth weight, . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa040576</identifier><identifier>PMID: 15483280</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Birth Weight ; Body Height ; Body Mass Index ; Breast cancer ; Breast Neoplasms - etiology ; Child ; Clinical trials ; Cohort Studies ; Female ; General aspects ; Growth ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Mammary gland diseases ; Medical sciences ; Menarche ; Parity ; Risk Factors ; Tumors ; Women</subject><ispartof>The New England journal of medicine, 2004-10, Vol.351 (16), p.1619-1626</ispartof><rights>Copyright © 2004 Massachusetts Medical Society. All rights reserved.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-a78145b7f11338f0bdc6b481123b173f5d967b61839fc58f0761852e9884cc073</citedby><cites>FETCH-LOGICAL-c599t-a78145b7f11338f0bdc6b481123b173f5d967b61839fc58f0761852e9884cc073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa040576$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223936909?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,2761,2762,26110,27931,27932,52389,54071,64392,64394,64396,72476</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16180090$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15483280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahlgren, Martin</creatorcontrib><creatorcontrib>Melbye, Mads</creatorcontrib><creatorcontrib>Wohlfahrt, Jan</creatorcontrib><creatorcontrib>Sørensen, Thorkild I. A</creatorcontrib><title>Growth Patterns and the Risk of Breast Cancer in Women</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this study, associations between breast cancer and patterns of growth during childhood were analyzed in the school health records of 117,415 Danish women. High birth weight, a young age at peak growth, and high stature and low body-mass index at 14 years of age were all independent risk factors for breast cancer in adulthood. The mechanisms of these associations are unknown, but the data indicate that growth during childhood influences the risk of breast cancer during adult life.
Patterns of growth analyzed in the school health records of 117,415 Danish women indicate that growth during childhood influences the risk of breast cancer.
Most studies of body size and the risk of breast cancer have shown that tall women have an increased risk of breast cancer regardless of menopausal status,
1
whereas obese women have a reduced risk of breast cancer before menopause but an increased risk after menopause.
2
The extent to which these associations in adults reflect growth patterns in early life is unknown. A better understanding of the association between early growth patterns and the risk of breast cancer could improve our knowledge of the mechanisms of the disease and could be important for prevention.
We explored possible associations among birth weight, . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Body Height</subject><subject>Body Mass Index</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - etiology</subject><subject>Child</subject><subject>Clinical trials</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>General aspects</subject><subject>Growth</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Menarche</subject><subject>Parity</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>Women</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0M1LwzAYBvAgipvTm2cJop6sJs33UcecyvxAFI8lTVPs7MdMWsT_3owVJiL4XvIefjzhfQDYx-gMI8bP7ye3d41GFDHBN8AQM0IiShHfBEOEYhlRocgA7Hg_R2EwVdtggBmVJJZoCPjUNZ_tG3zUbWtd7aGuM9i-WfhU-HfY5PDSWe1bONa1sQ4WNXxtKlvvgq1cl97u9e8IvFxNnsfX0exhejO-mEWGKdVGWkhMWSpyjAmROUozw1MqMY5JigXJWaa4SDmWROWGBSDCzmKrpKTGIEFG4GSVu3DNR2d9m1SFN7YsdW2bziecK64QIf9CLIRQMZIBHv6C86ZzdTgiiWOiSIhTAZ2ukHGN987mycIVlXZfCUbJsvXkZ-uBH_SZXVrZbI37mgM47oH2Rpe5C20Wfu3C1QippTtauarySW3n1d__fQOlKJDz</recordid><startdate>20041014</startdate><enddate>20041014</enddate><creator>Ahlgren, Martin</creator><creator>Melbye, Mads</creator><creator>Wohlfahrt, Jan</creator><creator>Sørensen, Thorkild I. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth Patterns and the Risk of Breast Cancer in Women</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2004-10-14</date><risdate>2004</risdate><volume>351</volume><issue>16</issue><spage>1619</spage><epage>1626</epage><pages>1619-1626</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>In this study, associations between breast cancer and patterns of growth during childhood were analyzed in the school health records of 117,415 Danish women. High birth weight, a young age at peak growth, and high stature and low body-mass index at 14 years of age were all independent risk factors for breast cancer in adulthood. The mechanisms of these associations are unknown, but the data indicate that growth during childhood influences the risk of breast cancer during adult life.
Patterns of growth analyzed in the school health records of 117,415 Danish women indicate that growth during childhood influences the risk of breast cancer.
Most studies of body size and the risk of breast cancer have shown that tall women have an increased risk of breast cancer regardless of menopausal status,
1
whereas obese women have a reduced risk of breast cancer before menopause but an increased risk after menopause.
2
The extent to which these associations in adults reflect growth patterns in early life is unknown. A better understanding of the association between early growth patterns and the risk of breast cancer could improve our knowledge of the mechanisms of the disease and could be important for prevention.
We explored possible associations among birth weight, . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>15483280</pmid><doi>10.1056/NEJMoa040576</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2004-10, Vol.351 (16), p.1619-1626 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adolescent Adult Age Factors Biological and medical sciences Birth Weight Body Height Body Mass Index Breast cancer Breast Neoplasms - etiology Child Clinical trials Cohort Studies Female General aspects Growth Gynecology. Andrology. Obstetrics Humans Infant, Newborn Mammary gland diseases Medical sciences Menarche Parity Risk Factors Tumors Women |
| title | Growth Patterns and the Risk of Breast Cancer in Women |
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