Noncanonical Function of Glutamyl-Prolyl-tRNA Synthetase: Gene-Specific Silencing of Translation

Aminoacyl tRNA synthetases (ARS) catalyze the ligation of amino acids to cognate tRNAs. Chordate ARSs have evolved distinctive features absent from ancestral forms, including compartmentalization in a multisynthetase complex (MSC), noncatalytic peptide appendages, and ancillary functions unrelated t...

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Veröffentlicht in:	Cell 2004-10, Vol.119 (2), p.195-208
Hauptverfasser:	Sampath, Prabha, Mazumder, Barsanjit, Seshadri, Vasudevan, Gerber, Carri A., Chavatte, Laurent, Kinter, Michael, Ting, Shu M., Dignam, J.David, Kim, Sunghoon, Driscoll, Donna M., Fox, Paul L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acyl-tRNA Synthetases - metabolism Animals Cell Line Ceruloplasmin - genetics Ceruloplasmin - metabolism Chromatography, Affinity Gene Expression Regulation Gene Silencing Humans Inflammation - genetics Inflammation - metabolism Interferon-gamma - metabolism Ligands Macromolecular Substances Nucleic Acid Conformation Phosphorylation Protein Biosynthesis Ribonucleoproteins - chemistry Ribonucleoproteins - metabolism
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