Molecular Basis of Distinct Interactions Between Dok1 PTB Domain and Tyrosine-phosphorylated EGF Receptor

Phosphotyrosine binding (PTB) domains of the adaptor proteins Doks (downstream of tyrosine kinases) play an important role in regulating signal transduction of cell-surface receptors in cell growth, proliferation and differentiation; however, ligand specificity of the Dok PTB domains has until now r...

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Veröffentlicht in:	Journal of molecular biology 2004-10, Vol.343 (4), p.1147-1155
Hauptverfasser:	Zhang, Yong, Yan, Zhiyong, Farooq, Amjad, Liu, Xiujie, Lu, Changlin, Zhou, Ming-Ming, He, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dok1 EGF receptor Humans Mutation Phosphoproteins - chemistry Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation phosphotyrosine domain Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Two-Hybrid System Techniques Tyrosine - metabolism tyrosine phosphorylation yeast two-hybrid
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