Cadherin-20 expression by motor neurons is regulated by Sonic hedgehog during spinal cord development
During chicken spinal cord development, cadherin-20 is expressed by motor neurons of the lateral motor column and other cells in the basal and alar plates. To investigate the regulation of cadherin-20 expression, Sonic hedgehog (Shh) signaling was altered in chicken spinal cord and hindbrain by in-v...
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| Veröffentlicht in: | Neuroreport 2009-03, Vol.20 (4), p.365-370 |
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| creator | Luo, Jiankai Ju, Min Jeong Lin, Juntang Yan, Xin Markus, Annett Mix, Eilhard Rolfs, Arndt Redies, Christoph |
| description | During chicken spinal cord development, cadherin-20 is expressed by motor neurons of the lateral motor column and other cells in the basal and alar plates. To investigate the regulation of cadherin-20 expression, Sonic hedgehog (Shh) signaling was altered in chicken spinal cord and hindbrain by in-vivo electroporation. Our results show that, at an early embryonic stage 12, Shh induces cadherin-20 expression by motor neurons. Later, at stage 24 when the sorting of motor neuron pools begins, cadherin-20 expression is induced in the neural progenitors of the ventricular zone but not in motor neurons. Blockage of Shh signaling inhibits cadherin-20 expression in the motor column. Therefore, cadherin-20 expression in motor neurons is regulated by Shh in a time-dependent manner. |
| doi_str_mv | 10.1097/WNR.0b013e3283243fe4 |
| format | Article |
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To investigate the regulation of cadherin-20 expression, Sonic hedgehog (Shh) signaling was altered in chicken spinal cord and hindbrain by in-vivo electroporation. Our results show that, at an early embryonic stage 12, Shh induces cadherin-20 expression by motor neurons. Later, at stage 24 when the sorting of motor neuron pools begins, cadherin-20 expression is induced in the neural progenitors of the ventricular zone but not in motor neurons. Blockage of Shh signaling inhibits cadherin-20 expression in the motor column. Therefore, cadherin-20 expression in motor neurons is regulated by Shh in a time-dependent manner.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/WNR.0b013e3283243fe4</identifier><identifier>PMID: 19218874</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Apoptosis ; Biological and medical sciences ; Cadherins - genetics ; Cadherins - metabolism ; Chick Embryo ; Development. Senescence. Regeneration. Transplantation ; Electroporation ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Developmental ; Hedgehog Proteins - genetics ; Hedgehog Proteins - metabolism ; Immunohistochemistry ; In Situ Hybridization ; In Situ Nick-End Labeling ; Motor Neurons - metabolism ; Rhombencephalon - embryology ; Rhombencephalon - metabolism ; Spinal Cord - embryology ; Spinal Cord - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2009-03, Vol.20 (4), p.365-370</ispartof><rights>2009 Lippincott Williams & Wilkins, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4154-a9d37bc1eb7e7e00997c59ad830765d5695e6b9a63f78fb66344bbc1da7f92ac3</citedby><cites>FETCH-LOGICAL-c4154-a9d37bc1eb7e7e00997c59ad830765d5695e6b9a63f78fb66344bbc1da7f92ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21290028$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19218874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Jiankai</creatorcontrib><creatorcontrib>Ju, Min Jeong</creatorcontrib><creatorcontrib>Lin, Juntang</creatorcontrib><creatorcontrib>Yan, Xin</creatorcontrib><creatorcontrib>Markus, Annett</creatorcontrib><creatorcontrib>Mix, Eilhard</creatorcontrib><creatorcontrib>Rolfs, Arndt</creatorcontrib><creatorcontrib>Redies, Christoph</creatorcontrib><title>Cadherin-20 expression by motor neurons is regulated by Sonic hedgehog during spinal cord development</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>During chicken spinal cord development, cadherin-20 is expressed by motor neurons of the lateral motor column and other cells in the basal and alar plates. 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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Animals Apoptosis Biological and medical sciences Cadherins - genetics Cadherins - metabolism Chick Embryo Development. Senescence. Regeneration. Transplantation Electroporation Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Immunohistochemistry In Situ Hybridization In Situ Nick-End Labeling Motor Neurons - metabolism Rhombencephalon - embryology Rhombencephalon - metabolism Spinal Cord - embryology Spinal Cord - metabolism Vertebrates: nervous system and sense organs |
| title | Cadherin-20 expression by motor neurons is regulated by Sonic hedgehog during spinal cord development |
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