Exposure of the mouse perinatal testis to radiation leads to hypospermia at sexual maturity
The first round of mouse spermatogenesis begins from 3 to 4 days after birth through differentiation of gonocytes into spermatogonial-stem cells and type A spermatogonia. Consequently, this step of differentiation may determine generation of the original population of stem cells and the fertility po...
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| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2009-03, Vol.137 (3), p.487-495 |
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| creator | Forand, A Messiaen, S Habert, R Bernardino-Sgherri, J |
| description | The first round of mouse spermatogenesis begins from 3 to 4 days after birth through differentiation of gonocytes into spermatogonial-stem cells and type A spermatogonia. Consequently, this step of differentiation may determine generation of the original population of stem cells and the fertility potential of the adult mouse. We aimed to determine the effect of perinatal exposure to ionizing radiation on the testis at the end of the first wave of spermatogenesis and at sexual maturity. Our results show that, radiation sensitivity of the testis substantially decreases from late foetal life to the end of the first week after birth. In addition, partial or full recovery from radiation induced testicular weight loss occurred between the first round of spermatogenesis and sexual maturity, and this was associated with the stimulation of spermatogonial proliferation. Exposure of mice at 17.5 days after conception or at 1 day after birth to γ-rays decreased the sperm counts at sexual maturity, while exposure of 8 day-old mice had no effect. This suggests that irradiation of late foetal or early neonatal testes has a direct impact on the generation of the neonatal spermatogonial-stem cell pool. |
| doi_str_mv | 10.1530/REP-08-0358 |
| format | Article |
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This suggests that irradiation of late foetal or early neonatal testes has a direct impact on the generation of the neonatal spermatogonial-stem cell pool.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Female</subject><subject>Fertility - radiation effects</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Sexual Maturation</subject><subject>Spermatogenesis - radiation effects</subject><subject>Testis - embryology</subject><subject>Testis - growth & development</subject><subject>Testis - radiation effects</subject><subject>Whole-Body Irradiation</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS1ERcuWE3fwiQtKa8dJbB9RtUClSqBCTxysSTzuGiXrxXbU7r_HbRYVceA0o9H3nmbeEPKaszPeCnZ-vf5aMVUx0apn5ITLhldSaf289I1kFe_q7pi8TOknY7xVsntBjrnmTAshTsiP9f0upDkiDY7mDdIpzAnpDqPfQoaRZkzZJ5oDjWA9ZB-2dESwj6PNvogLO3mgkGnC-7lIJshz9Hl_So4cjAlfHeqK3Hxcf7_4XF19-XR58eGq6lvBcwVM2AbagVkYlNKycYittuAU8E5YrmUPPTJZayfazoKUCnXTuL63tQNsxYq8W3x3Mfyay75m8mnAcYQtlmtM1-lOMFEX8P0CDjGkFNGZXfQTxL3hzDxkaUqWhinzkGWh3xxs535C-8QewitAvQAbf7u58xFN70MaPG6zd36Av13_fKiI3i4iB8HAbfTJ3HyrGRflOVrpcvGK8IX4x-1_u_4GITqa4w</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Forand, A</creator><creator>Messiaen, S</creator><creator>Habert, R</creator><creator>Bernardino-Sgherri, J</creator><general>BioScientifica</general><general>BioScientifica Ltd</general><general>Society for Reproduction and Fertility</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Exposure of the mouse perinatal testis to radiation leads to hypospermia at sexual maturity</title><author>Forand, A ; Messiaen, S ; Habert, R ; Bernardino-Sgherri, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b531t-a03d4a5c0dac88974fee59daf8a163d197babe0729f356da778e944fbbd2fae53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Female</topic><topic>Fertility - radiation effects</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Sexual Maturation</topic><topic>Spermatogenesis - radiation effects</topic><topic>Testis - embryology</topic><topic>Testis - growth & development</topic><topic>Testis - radiation effects</topic><topic>Whole-Body Irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forand, A</creatorcontrib><creatorcontrib>Messiaen, S</creatorcontrib><creatorcontrib>Habert, R</creatorcontrib><creatorcontrib>Bernardino-Sgherri, J</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forand, A</au><au>Messiaen, S</au><au>Habert, R</au><au>Bernardino-Sgherri, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure of the mouse perinatal testis to radiation leads to hypospermia at sexual maturity</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>137</volume><issue>3</issue><spage>487</spage><epage>495</epage><pages>487-495</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>The first round of mouse spermatogenesis begins from 3 to 4 days after birth through differentiation of gonocytes into spermatogonial-stem cells and type A spermatogonia. 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| subjects | Animals Animals, Newborn Female Fertility - radiation effects Immunohistochemistry Male Mice Mice, Inbred Strains Pregnancy Prenatal Exposure Delayed Effects Sexual Maturation Spermatogenesis - radiation effects Testis - embryology Testis - growth & development Testis - radiation effects Whole-Body Irradiation |
| title | Exposure of the mouse perinatal testis to radiation leads to hypospermia at sexual maturity |
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