Human immunodeficiency virus type 1-anchored CD40 ligand induces secretion of the chemokine interleukin-8 by human primary macrophages

Abstract CD40 ligand (CD40L) is mainly expressed in activated CD4+ T cells and interacts with CD40 on antigen-presenting cells to regulate both humoral and cellular immune responses. We previously reported that CD40L is acquired by emerging HIV-1 particles. Here we demonstrate that both wild-type an...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2009-03, Vol.385 (1), p.227-232
Hauptverfasser:	Maurais, Émilie, Cantin, Réjean, Tremblay, Michel J
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS CD40 Ligand - genetics CD40 Ligand - immunology CD40 Ligand - metabolism Cell Line Cells, Cultured HIV HIV Infections - immunology HIV Infections - metabolism HIV-1 - metabolism Human Human immunodeficiency virus 1 Humans Infectious Disease Interleukin-8 - immunology Interleukin-8 - metabolism Interleukin-8 - secretion Macrophage Macrophages - immunology Macrophages - metabolism Macrophages - virology Mutation
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