Obesity Is Associated With Altered Lung Function Independently of Physical Activity and Fitness
Measures of obesity, especially central adiposity, have been associated with reduced lung function. However, previous studies may have been affected by confounding by physical activity and fitness. This study aimed to examine the relationship among body fatness, fat distribution, and lung function,...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2009-03, Vol.17 (3), p.578-584 |
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| creator | Steele, Rebekah M Finucane, Francis M Griffin, Simon J Wareham, Nicholas J Ekelund, Ulf |
| description | Measures of obesity, especially central adiposity, have been associated with reduced lung function. However, previous studies may have been affected by confounding by physical activity and fitness. This study aimed to examine the relationship among body fatness, fat distribution, and lung function, adjusted for physical activity energy expenditure (PAEE) and aerobic fitness (VO2max), in a cohort of British white adults with a family history of type 2 diabetes. A total of 320 adults (mean age 40.4 ± 6.0 years) attended for anthropometric and VO2max testing, and had ambulatory heart rate monitoring for 4 days to determine PAEE. Spirometry was used to measure forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). The tests were repeated 12 months later, and a cross‐sectional analysis using linear regression with repeated measures was performed. Measures of obesity (BMI, waist circumference (WC), fat mass (FM), body fat percentage (BF%)) were associated with lower lung function in men and women (P < 0.01), while waist‐to‐hip ratio (WHR) was associated with lower lung function in men only (P < 0.001). Associations remained after adjusting for age, smoking status, height, PAEE, and VO2max. The estimated difference in mean FEV1 and FVC per unit increase in the exposure measures were consistently stronger in men compared to women (P for interaction |
| doi_str_mv | 10.1038/oby.2008.584 |
| format | Article |
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Measures of obesity (BMI, waist circumference (WC), fat mass (FM), body fat percentage (BF%)) were associated with lower lung function in men and women (P < 0.01), while waist‐to‐hip ratio (WHR) was associated with lower lung function in men only (P < 0.001). Associations remained after adjusting for age, smoking status, height, PAEE, and VO2max. The estimated difference in mean FEV1 and FVC per unit increase in the exposure measures were consistently stronger in men compared to women (P for interaction <0.001). Obesity is inversely associated with lung function in adults, but central fat distribution appears to have a stronger relationship with respiratory mechanics in men than in women. 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However, previous studies may have been affected by confounding by physical activity and fitness. This study aimed to examine the relationship among body fatness, fat distribution, and lung function, adjusted for physical activity energy expenditure (PAEE) and aerobic fitness (VO2max), in a cohort of British white adults with a family history of type 2 diabetes. A total of 320 adults (mean age 40.4 ± 6.0 years) attended for anthropometric and VO2max testing, and had ambulatory heart rate monitoring for 4 days to determine PAEE. Spirometry was used to measure forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). The tests were repeated 12 months later, and a cross‐sectional analysis using linear regression with repeated measures was performed. Measures of obesity (BMI, waist circumference (WC), fat mass (FM), body fat percentage (BF%)) were associated with lower lung function in men and women (P < 0.01), while waist‐to‐hip ratio (WHR) was associated with lower lung function in men only (P < 0.001). Associations remained after adjusting for age, smoking status, height, PAEE, and VO2max. The estimated difference in mean FEV1 and FVC per unit increase in the exposure measures were consistently stronger in men compared to women (P for interaction <0.001). Obesity is inversely associated with lung function in adults, but central fat distribution appears to have a stronger relationship with respiratory mechanics in men than in women. These associations were independent of the degree of physical activity and aerobic fitness in this cohort.</description><subject>Adult</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Body Fat Distribution</subject><subject>body mass index</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Energy</subject><subject>Energy Metabolism - physiology</subject><subject>epidemiological studies</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Family medical history</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Heart rate</subject><subject>Humans</subject><subject>lifestyle</subject><subject>Longitudinal studies</subject><subject>Lung - physiopathology</subject><subject>lungs</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>overweight</subject><subject>Oxygen Consumption - physiology</subject><subject>physical activity</subject><subject>Physical fitness</subject><subject>Physical Fitness - physiology</subject><subject>Research ethics</subject><subject>Respiratory Mechanics - physiology</subject><subject>respiratory physiology</subject><subject>Sex Characteristics</subject><subject>Spirometry</subject><subject>Vital Capacity - physiology</subject><subject>waist circumference</subject><subject>waist-to-hip ratio</subject><subject>Women</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M2LEzEYB-AgivuhN88aEPZka94kkybHulgtFCroop5CJpPuZpkm3SSjzH9vypQVPAj5hOd9E34IvQIyB8Lk-9iOc0qInDeSP0HnoBiZLZj68fTxLOEMXeR8TwgXpIHn6AwUBUUEOUd627rsy4jXGS9zjtab4jr83Zc7vOyLS_WyGcItXg3BFh8DXofOHVxdQulHHHf4y92YvTU9Xlbw69jLhA6vfAku5xfo2c702b087ZfoZvXx2_Xn2Wb7aX293Mws50LOgEJLqBKGQp28js5KJRrgTLXStJZRKhuQbde0ZCE7QTi3nADrGskAGLtEV1PfQ4oPg8tF7322ru9NcHHIWgglgDJa4dt_4H0cUqh_0zXOGmhFsqp3k7Ip5pzcTh-S35s0VnR0UtfY9TF2XWOv_PWp6dDuXfcXn3KuACbw2_du_G8zvf3wE6Y_4KkmmDIk91hU8dFO776ZyM5EbW6Tz_rmK62xEBALoWDB_gBWkZ8I</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Steele, Rebekah M</creator><creator>Finucane, Francis M</creator><creator>Griffin, Simon J</creator><creator>Wareham, Nicholas J</creator><creator>Ekelund, Ulf</creator><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200903</creationdate><title>Obesity Is Associated With Altered Lung Function Independently of Physical Activity and Fitness</title><author>Steele, Rebekah M ; Finucane, Francis M ; Griffin, Simon J ; Wareham, Nicholas J ; Ekelund, Ulf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4468-121b0296a216a24a24dc89651439b8abc3228518bd5b078d6044c4013d5831133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Body Fat Distribution</topic><topic>body mass index</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Energy</topic><topic>Energy Metabolism - physiology</topic><topic>epidemiological studies</topic><topic>Epidemiology</topic><topic>Exercise</topic><topic>Family medical history</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Heart rate</topic><topic>Humans</topic><topic>lifestyle</topic><topic>Longitudinal studies</topic><topic>Lung - physiopathology</topic><topic>lungs</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Motor Activity - physiology</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>overweight</topic><topic>Oxygen Consumption - physiology</topic><topic>physical activity</topic><topic>Physical fitness</topic><topic>Physical Fitness - physiology</topic><topic>Research ethics</topic><topic>Respiratory Mechanics - physiology</topic><topic>respiratory physiology</topic><topic>Sex Characteristics</topic><topic>Spirometry</topic><topic>Vital Capacity - physiology</topic><topic>waist circumference</topic><topic>waist-to-hip ratio</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steele, Rebekah M</creatorcontrib><creatorcontrib>Finucane, Francis M</creatorcontrib><creatorcontrib>Griffin, Simon J</creatorcontrib><creatorcontrib>Wareham, Nicholas J</creatorcontrib><creatorcontrib>Ekelund, Ulf</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steele, Rebekah M</au><au>Finucane, Francis M</au><au>Griffin, Simon J</au><au>Wareham, Nicholas J</au><au>Ekelund, Ulf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity Is Associated With Altered Lung Function Independently of Physical Activity and Fitness</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2009-03</date><risdate>2009</risdate><volume>17</volume><issue>3</issue><spage>578</spage><epage>584</epage><pages>578-584</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Measures of obesity, especially central adiposity, have been associated with reduced lung function. However, previous studies may have been affected by confounding by physical activity and fitness. This study aimed to examine the relationship among body fatness, fat distribution, and lung function, adjusted for physical activity energy expenditure (PAEE) and aerobic fitness (VO2max), in a cohort of British white adults with a family history of type 2 diabetes. A total of 320 adults (mean age 40.4 ± 6.0 years) attended for anthropometric and VO2max testing, and had ambulatory heart rate monitoring for 4 days to determine PAEE. Spirometry was used to measure forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). The tests were repeated 12 months later, and a cross‐sectional analysis using linear regression with repeated measures was performed. Measures of obesity (BMI, waist circumference (WC), fat mass (FM), body fat percentage (BF%)) were associated with lower lung function in men and women (P < 0.01), while waist‐to‐hip ratio (WHR) was associated with lower lung function in men only (P < 0.001). Associations remained after adjusting for age, smoking status, height, PAEE, and VO2max. The estimated difference in mean FEV1 and FVC per unit increase in the exposure measures were consistently stronger in men compared to women (P for interaction <0.001). Obesity is inversely associated with lung function in adults, but central fat distribution appears to have a stronger relationship with respiratory mechanics in men than in women. These associations were independent of the degree of physical activity and aerobic fitness in this cohort.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19219060</pmid><doi>10.1038/oby.2008.584</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Body composition Body fat Body Fat Distribution body mass index Cohort Studies Cross-Sectional Studies Diabetes Energy Energy Metabolism - physiology epidemiological studies Epidemiology Exercise Family medical history Female Forced Expiratory Volume - physiology Heart rate Humans lifestyle Longitudinal studies Lung - physiopathology lungs Male Metabolism Middle Aged Motor Activity - physiology Obesity Obesity - physiopathology overweight Oxygen Consumption - physiology physical activity Physical fitness Physical Fitness - physiology Research ethics Respiratory Mechanics - physiology respiratory physiology Sex Characteristics Spirometry Vital Capacity - physiology waist circumference waist-to-hip ratio Women |
| title | Obesity Is Associated With Altered Lung Function Independently of Physical Activity and Fitness |
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