Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells

The physiological role of the prion protein is largely unknown. Here, clustering of prion at the surface of GT1-7 cells was observed upon anti-prion antibody treatments. This clustering was associated with a rapid and transient phosphorylation of the mitogen activated protein kinases (MAPKs) extrace...

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Veröffentlicht in:	FEBS letters 2004-10, Vol.576 (1), p.114-118
Hauptverfasser:	Monnet, Céline, Gavard, Julie, Mège, René-Marc, Sobel, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - metabolism Blotting, Western Butadienes - pharmacology Cells, Cultured Clustering EGF receptor EGFR, epidermal growth factor receptor Enzyme Inhibitors - pharmacology ERK, extracellular receptor kinase Fluorescent Antibody Technique, Indirect GPI, glycosylphosphatidylinositol mAb, monoclonal antibody MAP kinase MAPK, mitogen activated protein kinase Mice Microscopy, Confocal Microtubule Proteins - metabolism Mitogen-Activated Protein Kinase 1 - drug effects Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - drug effects Mitogen-Activated Protein Kinase 3 - metabolism MKK, MAPK/ERK kinase Neurons - physiology Nitriles - pharmacology PBS, phosphate-buffered saline Phosphoproteins - metabolism Phosphorylation - drug effects Prion signaling PrPC Proteins - physiology PrPc, cellular prion protein PrPsc, scrapie prion protein Quinazolines RNA, Small Interfering - antagonists & inhibitors ROS, reactive oxygen species siRNA siRNA, small interfering RNA Stathmin Tyrphostins - pharmacology
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