Pre-mRNA processing reaches back to transcription and ahead to translation

Pre-mRNA processing reaches back to transcription and ahead to translation

The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the ef...

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Veröffentlicht in:Cell 2009-02, Vol.136 (4), p.688-700
Hauptverfasser: Moore, Melissa J, Proudfoot, Nick J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Feedback
Gene Expression Regulation
Humans
Protein Biosynthesis
RNA Precursors - metabolism
RNA Processing, Post-Transcriptional
RNA Stability
Transcription, Genetic
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container_title Cell
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creator Moore, Melissa J
Proudfoot, Nick J
description The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.
doi_str_mv 10.1016/j.cell.2009.02.001
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source MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present)
subjects Animals
Feedback
Gene Expression Regulation
Humans
Protein Biosynthesis
RNA Precursors - metabolism
RNA Processing, Post-Transcriptional
RNA Stability
Transcription, Genetic
title Pre-mRNA processing reaches back to transcription and ahead to translation
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