Monofocal large inflammatory demyelinating lesion, mimicking brain glioma
Abstract Here we report two cases of pathologically confirmed tumor-like demyelinating lesions. In comparison with common primary demyelinating diseases, our cases demonstrated atypical radiologic features, such as a large monofocal lesion with mild brain edema, and open ring-like or focal enhanceme...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2009-04, Vol.111 (3), p.296-299 |
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| container_title | Clinical neurology and neurosurgery |
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| creator | Kimura, Noriyuki Kumamoto, Toshihide Hanaoka, Takuya Hasama, Yusuke Nakamura, Kenichiro Okazaki, Toshio |
| description | Abstract Here we report two cases of pathologically confirmed tumor-like demyelinating lesions. In comparison with common primary demyelinating diseases, our cases demonstrated atypical radiologic features, such as a large monofocal lesion with mild brain edema, and open ring-like or focal enhancement on magnetic resonance images, suggesting brain tumors. The clinical manifestations included focal neurologic signs due to the lesions, monophasic episodes without relapse over a long follow-up period, and efficacy of oral corticosteroid therapy. Histological analysis of brain biopsy specimens showed the inflammatory demyelination and preserved axons without tumor cells. The present cases suggest the importance of considering inflammatory demyelinating disease in the different diagnosis of monofocal tumor-like lesion. |
| doi_str_mv | 10.1016/j.clineuro.2008.10.010 |
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In comparison with common primary demyelinating diseases, our cases demonstrated atypical radiologic features, such as a large monofocal lesion with mild brain edema, and open ring-like or focal enhancement on magnetic resonance images, suggesting brain tumors. The clinical manifestations included focal neurologic signs due to the lesions, monophasic episodes without relapse over a long follow-up period, and efficacy of oral corticosteroid therapy. Histological analysis of brain biopsy specimens showed the inflammatory demyelination and preserved axons without tumor cells. The present cases suggest the importance of considering inflammatory demyelinating disease in the different diagnosis of monofocal tumor-like lesion.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2008.10.010</identifier><identifier>PMID: 19058908</identifier><identifier>CODEN: CNNSBV</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adrenal Cortex Hormones - therapeutic use ; Astrocytes - metabolism ; Biological and medical sciences ; Biopsy ; Brain - pathology ; Brain - surgery ; Brain biopsy ; Brain Edema - etiology ; Brain Edema - pathology ; Brain MRI ; Demyelinating Diseases - diagnosis ; Demyelinating Diseases - pathology ; Demyelinating Diseases - therapy ; Diagnosis, Differential ; Female ; Glioma ; Glioma - diagnosis ; Glioma - pathology ; Humans ; Macrophages - immunology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Monofocal demyelinating lesion ; Neurology ; Neurosurgery ; Steroid therapy ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><ispartof>Clinical neurology and neurosurgery, 2009-04, Vol.111 (3), p.296-299</ispartof><rights>Elsevier B.V.</rights><rights>2008 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-fdf04737828c63b46a216773e625235e7451d7a6b6aeb3bce6f10d03d7df40b83</citedby><cites>FETCH-LOGICAL-c479t-fdf04737828c63b46a216773e625235e7451d7a6b6aeb3bce6f10d03d7df40b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1033003119?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21365917$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19058908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimura, Noriyuki</creatorcontrib><creatorcontrib>Kumamoto, Toshihide</creatorcontrib><creatorcontrib>Hanaoka, Takuya</creatorcontrib><creatorcontrib>Hasama, Yusuke</creatorcontrib><creatorcontrib>Nakamura, Kenichiro</creatorcontrib><creatorcontrib>Okazaki, Toshio</creatorcontrib><title>Monofocal large inflammatory demyelinating lesion, mimicking brain glioma</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>Abstract Here we report two cases of pathologically confirmed tumor-like demyelinating lesions. In comparison with common primary demyelinating diseases, our cases demonstrated atypical radiologic features, such as a large monofocal lesion with mild brain edema, and open ring-like or focal enhancement on magnetic resonance images, suggesting brain tumors. The clinical manifestations included focal neurologic signs due to the lesions, monophasic episodes without relapse over a long follow-up period, and efficacy of oral corticosteroid therapy. Histological analysis of brain biopsy specimens showed the inflammatory demyelination and preserved axons without tumor cells. The present cases suggest the importance of considering inflammatory demyelinating disease in the different diagnosis of monofocal tumor-like lesion.</description><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Astrocytes - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Brain - pathology</subject><subject>Brain - surgery</subject><subject>Brain biopsy</subject><subject>Brain Edema - etiology</subject><subject>Brain Edema - pathology</subject><subject>Brain MRI</subject><subject>Demyelinating Diseases - diagnosis</subject><subject>Demyelinating Diseases - pathology</subject><subject>Demyelinating Diseases - therapy</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Glioma</subject><subject>Glioma - diagnosis</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Macrophages - immunology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monofocal demyelinating lesion</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Steroid therapy</subject><subject>Surgery (general aspects). 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| ispartof | Clinical neurology and neurosurgery, 2009-04, Vol.111 (3), p.296-299 |
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| subjects | Adrenal Cortex Hormones - therapeutic use Astrocytes - metabolism Biological and medical sciences Biopsy Brain - pathology Brain - surgery Brain biopsy Brain Edema - etiology Brain Edema - pathology Brain MRI Demyelinating Diseases - diagnosis Demyelinating Diseases - pathology Demyelinating Diseases - therapy Diagnosis, Differential Female Glioma Glioma - diagnosis Glioma - pathology Humans Macrophages - immunology Magnetic Resonance Imaging Male Medical sciences Middle Aged Monofocal demyelinating lesion Neurology Neurosurgery Steroid therapy Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases |
| title | Monofocal large inflammatory demyelinating lesion, mimicking brain glioma |
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