Optimal windows of statin use for immediate infarct limitation: 5'-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase

Although statins are reported to have a cardioprotective effect, their immediate direct influence on ischemia-reperfusion injury and the underlying mechanisms remain obscure. We investigated these issues an in vivo canine model. Dogs were subjected to coronary occlusion (90 minutes) and reperfusion...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-10, Vol.110 (15), p.2143-2149
Hauptverfasser:	SANADA, Shoji, ASANUMA, Hiroshi, KIM, Jiyoong, ASANO, Yoshihiro, MORI, Hidezo, TOMOIKE, Hitonobu, KITAMURA, Soichiro, HORI, Masatsugu, KITAKAZE, Masafumi, MINAMINO, Tetsuo, NODE, Koichi, TAKASHIMA, Seiji, OKUDA, Hiroko, SHINOZAKI, Yoshiro, OGAI, Akiko, FUJITA, Masashi, HIRATA, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase - physiology Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Androstadienes - pharmacology Animals Associated diseases and complications Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiotonic Agents - administration & dosage Cardiotonic Agents - pharmacology Chromones - pharmacology Coronary Disease - complications Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dogs Dose-Response Relationship, Drug Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Activation - drug effects General and cellular metabolism. Vitamins Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Medical sciences Morpholines - pharmacology Myocardial Infarction - etiology Myocardial Infarction - pathology Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Pravastatin - administration & dosage Pravastatin - pharmacology Pravastatin - therapeutic use Pyridines - administration & dosage Pyridines - pharmacology Pyridines - therapeutic use Quinolines - administration & dosage Quinolines - pharmacology Quinolines - therapeutic use Signal Transduction - drug effects Theophylline - analogs & derivatives Theophylline - pharmacology
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