Cardiovascular effects of sildenafil in hypertensive men with erectile dysfunction and different alleles of the type 5 cGMP-specific phosphodiesterase (PDE5)

Erectile dysfunction (ED) is frequent in patients with essential hypertension (EH); a likely common pathogenetic pathway could be a reduced ability of arteriolar vascular smooth muscle (VSM) to relax. Increasing intracellular levels of cGMP reduce the contractile status of VSM; on the contrary, type...

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Veröffentlicht in:	International journal of impotence research 2004-10, Vol.16 (5), p.412-417
Hauptverfasser:	Salvi, F, Sarzani, R, Giorgi, R, Donatelli, G, Pietrucci, F, Micheli, A, Baldoni, M, Minaroli, D, Dessì-Fulgheri, P, Polito, M, Muzzonigro, G, Rappelli, A
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-GMP Phosphodiesterases - biosynthesis 3',5'-Cyclic-GMP Phosphodiesterases - genetics 5' Flanking Region - genetics Adult Aged Alleles Biological and medical sciences Cyclic Nucleotide Phosphodiesterases, Type 5 DNA - genetics Erectile dysfunction Erectile Dysfunction - complications Erectile Dysfunction - genetics Erectile Dysfunction - physiopathology Genotype Genotype & phenotype Gynecology. Andrology. Obstetrics Hemodynamics - drug effects Humans Hypertension Hypertension - complications Hypertension - genetics Hypertension - physiopathology Male Male genital diseases Medical sciences Medicine Medicine & Public Health Middle Aged Non tumoral diseases original-research Piperazines - pharmacology Polymorphism Purines Reproductive Medicine Reverse Transcriptase Polymerase Chain Reaction rology Sildenafil Citrate Sulfones Transcription Factor AP-1 - genetics Urology Vasodilator Agents - pharmacology
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