Water balance and kidney function in the least shrew ( Cryptotis parva)

We assessed renal function in least shrews ( Cryptotis parva, body mass 4.7 g) within the context of overall water balance. The glomerular filtration rate (GFR) of shrews with unlimited food and water was 2.4 ml/h, about 60% of the rate predicted from body mass. Of this, about 3% (0.075 ml/h) was ex...

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Veröffentlicht in:Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2004-09, Vol.139 (1), p.71-76
Hauptverfasser: Goldstein, David L., Newland, Stacy
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Sprache:eng
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Zusammenfassung:We assessed renal function in least shrews ( Cryptotis parva, body mass 4.7 g) within the context of overall water balance. The glomerular filtration rate (GFR) of shrews with unlimited food and water was 2.4 ml/h, about 60% of the rate predicted from body mass. Of this, about 3% (0.075 ml/h) was excreted as urine with an osmolality of 1944 mmol/kg, 5.5 times plasma osmolality. Shrews had a total water turnover (5 ml/day) two to three times higher than expected from allometry for a small mammal of this size. Water influx was partitioned among preformed water from food (65%), drinking (16%), and metabolic water (20%). Water efflux was divided among urine flow (35%), fecal water loss (estimated as 23%), and evaporation (by difference, 42%). Least shrews had a high water turnover rate and relatively high urine flow rate (UFR); this likely reflects a combination of factors, including high metabolism, active lifestyle, and wet diet.
ISSN:1095-6433
1531-4332
DOI:10.1016/j.cbpb.2004.07.003