The influence of Nos3 polymorphisms on age at menarche and natural menopause

Objective: Deficiency of the gene encoding endothelial nitric oxide synthase, i.e. Nos3, has been reported to be associated with late menarche, reduced ovulation rates, fewer deliveries, and earlier onset of menopause in a mouse model. Methods: We assessed the Glu298Asp and the T-786C polymorphisms...

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