Fenofibrate inhibits thrombogenic and fibrinolytic factors expression in adipose tissue of atherosclerotic rabbits

Tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) activity and/or expression are upregulated in obesity. We investigated TF and PAI-1 mRNA expression in adipose tissues of cholesterol-fed rabbits, and the effects of fenofibrate. Male rabbits were fed either a normal or high-cholestero...

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Veröffentlicht in:	Clinica chimica acta 2004-11, Vol.349 (1), p.81-86
Hauptverfasser:	Zhao, Shui-Ping, Li, Jieqi, XU, Zhumei, Wu, Jie, Li, Quanzhong, Ye, Huijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - metabolism Animals Arteriosclerosis - metabolism Atherosclerosis Cholesterol - blood Cholesterol, Dietary - pharmacology Diet Enzyme-Linked Immunosorbent Assay Fenofibrate Fenofibrate - pharmacology Fibrinolysis - drug effects Hypolipidemic Agents - pharmacology Male Plasminogen Activator Inhibitor 1 - biosynthesis Plasminogen Activator Inhibitor 1 - pharmacology Plasminogen activator inhibitor-1 Rabbits Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Thromboplastin - pharmacology Tissue factor
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