Molecular mechanism of KCl-induced relaxation of the esophagus

KCl (40 mM) caused reproducible relaxations in frog esophagus. N G-nitro- l-arginine (L-NOARG; 1–100 µM), a steriospecific inhibitor of nitric oxide synthase (NOS), completely inhibited the relaxations induced by KCl but not those induced by vasoactive intestinal polypeptide (VIP) antagonist. The in...

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Veröffentlicht in:	European journal of pharmacology 2009-03, Vol.605 (1), p.123-128
Hauptverfasser:	Yaktubay Döndaş, Naciye, Karataş, Yusuf, Kaya, Derya, Soylu, Neslihan, Şingirik, Ergin, Baysal, Firuz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dose-Response Relationship, Drug Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Esophagus Esophagus - drug effects Esophagus - metabolism Female Frog Intracellular Ca 2 K + channel KCl Male Medical sciences Muscle Relaxation - drug effects Na +–K +–ATPase Nitrergic neurotransmission Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - administration & dosage Nitroarginine - pharmacology Pharmacology. Drug treatments Potassium Channels - drug effects Potassium Channels - metabolism Potassium Chloride - pharmacology Rana pipiens Relaxation Sodium-Potassium-Exchanging ATPase - metabolism Stereoisomerism
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