Association of TGIFLX/Y mRNA expression with prostate cancer
Prostate cancer is the most common type of solid tumor and a leading cause of cancer-related death of men living in the developed world. In recent years, the molecular mechanisms involved in prostate cancer development and/or progression have been intensely studied and several genes have been identi...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2009-03, Vol.26 (1), p.73-77 |
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| container_title | Medical oncology (Northwood, London, England) |
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| creator | Ousati Ashtiani, Z. Ayati, M. Modarresi, M. H. Raoofian, R. Sabah Goulian, B. Greene, W. K. Heidari, M. |
| description | Prostate cancer is the most common type of solid tumor and a leading cause of cancer-related death of men living in the developed world. In recent years, the molecular mechanisms involved in prostate cancer development and/or progression have been intensely studied and several genes have been identified.
TGIFLX/Y
(
TGIFLX
and
TGIFLY
) are members of the homeobox superfamily of genes whose function(s) is unknown. To investigate
TGIFLX/Y
mRNA expression in prostate cancer, we studied two different types of clinical samples, namely 60 prostate tumors and 15 cases of benign prostate hyperplasia (BPH), by RT-PCR. Our results revealed that most prostate tumors (73.5%) express at least one of these genes, although different patterns of
TGIFLX/Y
mRNA expression were observed. In some tumor samples the expression of both genes was detected, while in others no expression of either gene was observed. Notably, there was a significant correlation between expression of both
TGIFLX
and
TGIFLY
and a Gleason score of ≥6 (
P
= 0.038). By contrast, expression of
TGIFLX/Y
mRNA in BPH samples could not be detected. These results suggest an association of
TGIFLX/Y
expression with the progression of prostate cancer. |
| doi_str_mv | 10.1007/s12032-008-9086-7 |
| format | Article |
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TGIFLX/Y
(
TGIFLX
and
TGIFLY
) are members of the homeobox superfamily of genes whose function(s) is unknown. To investigate
TGIFLX/Y
mRNA expression in prostate cancer, we studied two different types of clinical samples, namely 60 prostate tumors and 15 cases of benign prostate hyperplasia (BPH), by RT-PCR. Our results revealed that most prostate tumors (73.5%) express at least one of these genes, although different patterns of
TGIFLX/Y
mRNA expression were observed. In some tumor samples the expression of both genes was detected, while in others no expression of either gene was observed. Notably, there was a significant correlation between expression of both
TGIFLX
and
TGIFLY
and a Gleason score of ≥6 (
P
= 0.038). By contrast, expression of
TGIFLX/Y
mRNA in BPH samples could not be detected. These results suggest an association of
TGIFLX/Y
expression with the progression of prostate cancer.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-008-9086-7</identifier><identifier>PMID: 18663611</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Aged ; Aged, 80 and over ; Benign ; Gene expression ; Gene Expression Regulation, Neoplastic ; Hematology ; Homeobox ; Homeodomain Proteins - biosynthesis ; Homeodomain Proteins - genetics ; Humans ; Hyperplasia ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Molecular modelling ; Oncology ; Original Paper ; Pathology ; Polymerase chain reaction ; Prostate cancer ; Prostatic Hyperplasia - genetics ; Prostatic Hyperplasia - metabolism ; Prostatic Hyperplasia - pathology ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - biosynthesis ; Solid tumors ; Tumors</subject><ispartof>Medical oncology (Northwood, London, England), 2009-03, Vol.26 (1), p.73-77</ispartof><rights>Humana Press Inc. 2008</rights><rights>Humana Press Inc. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-519590dc0184cf95671d9fb47941a56298c78ae4965bc53589f5ec41b91294a03</citedby><cites>FETCH-LOGICAL-c478t-519590dc0184cf95671d9fb47941a56298c78ae4965bc53589f5ec41b91294a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-008-9086-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-008-9086-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18663611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ousati Ashtiani, Z.</creatorcontrib><creatorcontrib>Ayati, M.</creatorcontrib><creatorcontrib>Modarresi, M. H.</creatorcontrib><creatorcontrib>Raoofian, R.</creatorcontrib><creatorcontrib>Sabah Goulian, B.</creatorcontrib><creatorcontrib>Greene, W. K.</creatorcontrib><creatorcontrib>Heidari, M.</creatorcontrib><title>Association of TGIFLX/Y mRNA expression with prostate cancer</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>Prostate cancer is the most common type of solid tumor and a leading cause of cancer-related death of men living in the developed world. In recent years, the molecular mechanisms involved in prostate cancer development and/or progression have been intensely studied and several genes have been identified.
TGIFLX/Y
(
TGIFLX
and
TGIFLY
) are members of the homeobox superfamily of genes whose function(s) is unknown. To investigate
TGIFLX/Y
mRNA expression in prostate cancer, we studied two different types of clinical samples, namely 60 prostate tumors and 15 cases of benign prostate hyperplasia (BPH), by RT-PCR. Our results revealed that most prostate tumors (73.5%) express at least one of these genes, although different patterns of
TGIFLX/Y
mRNA expression were observed. In some tumor samples the expression of both genes was detected, while in others no expression of either gene was observed. Notably, there was a significant correlation between expression of both
TGIFLX
and
TGIFLY
and a Gleason score of ≥6 (
P
= 0.038). By contrast, expression of
TGIFLX/Y
mRNA in BPH samples could not be detected. These results suggest an association of
TGIFLX/Y
expression with the progression of prostate cancer.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Benign</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology</subject><subject>Homeobox</subject><subject>Homeodomain Proteins - biosynthesis</subject><subject>Homeodomain Proteins - genetics</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Molecular modelling</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Polymerase chain reaction</subject><subject>Prostate cancer</subject><subject>Prostatic Hyperplasia - genetics</subject><subject>Prostatic Hyperplasia - metabolism</subject><subject>Prostatic Hyperplasia - pathology</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Solid tumors</subject><subject>Tumors</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kV9LwzAUxYMobk4_gC9SfBBf6nKT5h_4Moabg6EgE-ZTSLNUO7Z2Ni3qtzelA0HQpwTu755z7z0InQO-AYzF0APBlMQYy1hhyWNxgPrAmIqBwvIw_CkTMWYc99CJ92uMCTCijlEPJOeUA_TR7cj70uamzssiKrNoMZ1N5svhS7R9ehhF7nNXOe_b2kdev0W7qvS1qV1kTWFddYqOMrPx7mz_DtDz5G4xvo_nj9PZeDSPbSJkHTNQTOGVxSATmynGBaxUliZCJWAYJ0paIY1LFGepZZRJlTFnE0gVEJUYTAfoqtMN_u-N87Xe5t66zcYUrmy85lyxhHARwOt_QQABUlBKVEAvf6HrsqmKsIaWgjEKwFtj6CAbFveVy_Suyrem-tKAdRuB7iLQIQLdRqDbGS72wk26daufjv3NA0A6wIdS8eqqH-e_Vb8BBqmNlg</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Ousati Ashtiani, Z.</creator><creator>Ayati, M.</creator><creator>Modarresi, M. H.</creator><creator>Raoofian, R.</creator><creator>Sabah Goulian, B.</creator><creator>Greene, W. K.</creator><creator>Heidari, M.</creator><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Association of TGIFLX/Y mRNA expression with prostate cancer</title><author>Ousati Ashtiani, Z. ; Ayati, M. ; Modarresi, M. H. ; Raoofian, R. ; Sabah Goulian, B. ; Greene, W. K. ; Heidari, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-519590dc0184cf95671d9fb47941a56298c78ae4965bc53589f5ec41b91294a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Benign</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology</topic><topic>Homeobox</topic><topic>Homeodomain Proteins - biosynthesis</topic><topic>Homeodomain Proteins - genetics</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Molecular modelling</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Polymerase chain reaction</topic><topic>Prostate cancer</topic><topic>Prostatic Hyperplasia - genetics</topic><topic>Prostatic Hyperplasia - metabolism</topic><topic>Prostatic Hyperplasia - pathology</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Solid tumors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ousati Ashtiani, Z.</creatorcontrib><creatorcontrib>Ayati, M.</creatorcontrib><creatorcontrib>Modarresi, M. 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H.</au><au>Raoofian, R.</au><au>Sabah Goulian, B.</au><au>Greene, W. K.</au><au>Heidari, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of TGIFLX/Y mRNA expression with prostate cancer</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>26</volume><issue>1</issue><spage>73</spage><epage>77</epage><pages>73-77</pages><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>Prostate cancer is the most common type of solid tumor and a leading cause of cancer-related death of men living in the developed world. In recent years, the molecular mechanisms involved in prostate cancer development and/or progression have been intensely studied and several genes have been identified.
TGIFLX/Y
(
TGIFLX
and
TGIFLY
) are members of the homeobox superfamily of genes whose function(s) is unknown. To investigate
TGIFLX/Y
mRNA expression in prostate cancer, we studied two different types of clinical samples, namely 60 prostate tumors and 15 cases of benign prostate hyperplasia (BPH), by RT-PCR. Our results revealed that most prostate tumors (73.5%) express at least one of these genes, although different patterns of
TGIFLX/Y
mRNA expression were observed. In some tumor samples the expression of both genes was detected, while in others no expression of either gene was observed. Notably, there was a significant correlation between expression of both
TGIFLX
and
TGIFLY
and a Gleason score of ≥6 (
P
= 0.038). By contrast, expression of
TGIFLX/Y
mRNA in BPH samples could not be detected. These results suggest an association of
TGIFLX/Y
expression with the progression of prostate cancer.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>18663611</pmid><doi>10.1007/s12032-008-9086-7</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1357-0560 |
| ispartof | Medical oncology (Northwood, London, England), 2009-03, Vol.26 (1), p.73-77 |
| issn | 1357-0560 1559-131X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66954267 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Aged, 80 and over Benign Gene expression Gene Expression Regulation, Neoplastic Hematology Homeobox Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Humans Hyperplasia Internal Medicine Male Medicine Medicine & Public Health Middle Aged Molecular modelling Oncology Original Paper Pathology Polymerase chain reaction Prostate cancer Prostatic Hyperplasia - genetics Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Solid tumors Tumors |
| title | Association of TGIFLX/Y mRNA expression with prostate cancer |
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