The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response

Cortisone, a glucocorticoid hormone, was first used to treat rheumatoid arthritis in humans in the late 1940s, for which Hench, Reichstein and Kendall were awarded a Nobel Prize in 1950 and which led to the discovery of the anti-inflammatory effects of glucocorticoids. To be effective, the intrinsic...

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Veröffentlicht in:	Molecular and cellular endocrinology 2009-03, Vol.301 (1-2), p.123-131
Hauptverfasser:	Chapman, Karen E, Coutinho, Agnes E, Gray, Mohini, Gilmour, James S, Savill, John S, Seckl, Jonathan R
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism Animals Gene Expression Regulation, Enzymologic Glucocorticoids - metabolism Humans Inflammation - enzymology Transcription, Genetic
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