Analysis of BRAF Point Mutation and RET/PTC Rearrangement Refines the Fine-Needle Aspiration Diagnosis of Papillary Thyroid Carcinoma

Point mutations in BRAF are genetic hallmarks of papillary thyroid carcinoma (PTC). In this retrospective study, we examined thyroid aspirates and corresponding paraffin-embedded surgical samples for the presence of BRAF mutations. Altogether, we examined 96 cases, including 69 PTCs, 19 follicular a...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2004-10, Vol.89 (10), p.5175-5180
Hauptverfasser:	Salvatore, Giuliana, Giannini, Riccardo, Faviana, Pinuccia, Caleo, Alessia, Migliaccio, Ilenia, Fagin, James A., Nikiforov, Yuri E., Troncone, Giancarlo, Palombini, Lucio, Basolo, Fulvio, Santoro, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Adult Biological and medical sciences Biomarkers, Tumor - genetics Biopsy, Fine-Needle Carcinoma, Papillary - genetics Carcinoma, Papillary - pathology Endocrinopathies Female Fundamental and applied biological sciences. Psychology Gene Rearrangement Humans Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Oncogene Proteins - genetics Oncogene Proteins, Fusion Point Mutation Protein-Tyrosine Kinases Proto-Oncogene Proteins B-raf - genetics Retrospective Studies Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases) Vertebrates: endocrinology
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